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Key Documents

44213

Sigma-Aldrich

Thromboplastin aus Kaninchen

Synonym(e):

Thromboplastin aus Kaninchenhirn, Faktor III, Thrombokinase

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About This Item

CAS-Nummer:
72162-96-0
EG-Nummer:
276-433-6
MDL-Nummer:
MFCD00148638
UNSPSC-Code:
12352202
NACRES:
NA.25

Biologische Quelle

rabbit

Qualitätsniveau

100

Form

lyophilized solid

UniProt-Hinterlegungsnummer

P24055

Lagertemp.

2-8°C

Angaben zum Gen

rabbit ... F3(100009127)

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Anwendung

Thromboplastin from rabbit has been used:
  • as a standard in tissue factor procoagulant activity assay (TF-PCA)
  • in pulmonary embolism assay
  • as a positive control in clotting assay using human plasma

Biochem./physiol. Wirkung

Thromboplastin (Tissue factor) is a transmembrane protein, the chief in vivo activator of blood coagulation that leads to thrombin generation and fibrin deposition. It is also important in the activation of the coagulation protease cascade and is involved in the lethality of sepsis.,
Thromboplastin from rabbit might be used to produce disseminated intravascular coagulation (DIC) in animal models.

Verpackung

Ein Vial enthält 3-4 mg Thromboplastin.

Rekonstituierung

reconstitute the content of 1 vial in 4 ml 10 mm CaCl2

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H334

Gefahreneinstufungen

Resp. Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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M E Bromberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8205-8209 (1995-08-29)
Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, and tumor metastasis. In the study reported here, a murine model of human melanoma
J Erlich et al.
Infection and immunity, 67(5), 2540-2546 (1999-05-04)
Tissue factor (TF) is the major activator of the coagulation protease cascade and contributes to lethality in sepsis. Despite several studies analyzing TF expression in animal models of endotoxemia, there remains debate about the cell types that are induced to
Nan Zhang et al.
The Journal of experimental medicine, 216(6), 1291-1300 (2019-05-03)
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in
Richard Beatson et al.
Communications biology, 3(1), 644-644 (2020-11-06)
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, phenotypic, functional and geographical diversity. Here

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