402M-1

Cathepsin K (3F9) Mouse Monoclonal Antibody

• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100; 500
• Konjugat: unconjugated
• Antikörperform: culture supernatant
• Antikörper-Produkttyp: primary antibodies
• Klon: 3F9, monoclonal
• Beschreibung: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Form: buffered aqueous solution
• Speziesreaktivität: human
• Verpackung: vial of 0.1 mL concentrate (402M-14); vial of 0.5 mL concentrate (402M-15); bottle of 1.0 mL predilute (402M-17); vial of 1.0 mL concentrate (402M-16); bottle of 7.0 mL predilute (402M-18)
• Hersteller/Markenname: Cell Marque^™
• Methode(n): immunohistochemistry: 1:25-1:100
• Isotyp: IgG2b
• Versandbedingung: wet ice
• Lagertemp.: 2-8°C
• Angaben zum Gen: human ... CTSK(1513)

Beschreibung

Allgemeine Beschreibung

Cathepsin K is a lysosomal papain–like cystine proteinase and can be expressed in normal osteoblasts, fibroblasts, and skin.1 Recently, cathepsin K has been reported as useful in distinguishing translocation renal cell carcinoma (RCC) from other subtypes of RCC.¹ Mortignoni et al. tested 17 cases of translocation RCC and found that cathepsin K stained 6 of 8 cases of translocation RCC with t(X;1), all seven cases of translocation RCC with t(6;11), but was negative for one case with t(X;3) and one with t(X;17).1 Additionally, the study compared IHC detection of TFE3 antibody in the 17 cases and demonstrated that all translocation RCC with t(6;11) were completely negative for TFE3, but positive for cathepsin K; all other translocation RCC with different chromosomal tranlocations other than t(X;1) expressed TFE3.¹ Thus, it is recommended that antibodies against both TFE3 and cathepsin K should be used for evaluating translocation renal cell carcinomas.¹ None of the 305 other renal cell neoplasms representing the most common renal cell neoplasm subtypes were positive for cathepsin K.1 Zheng et al. reported only 2.7% of 1,140 carcinomas from various organs exhibited cathepsin K labeling, indicating that among carcinomas cathepsin K labeling is highly specific for translocation RCC and can be used to help differentiate translocation RCC from other carcinomas.²

Qualität

IVD

IVD

IVD

RUO

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Angaben zur Herstellung

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Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable