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10791

Sigma-Aldrich

Antipain

>50000 U/mg

Synonym(e):

[(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal

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About This Item

Empirische Formel (Hill-System):
C27H44N10O6
CAS-Nummer:
37691-11-5
Molekulargewicht:
604.70
Beilstein:
6837629
EG-Nummer:
253-631-0
MDL-Nummer:
MFCD00135959
UNSPSC-Code:
12352202
PubChem Substanz-ID:
57646816
NACRES:
NA.77

Spezifische Aktivität

>50000 U/mg

Wirkungsweise

enzyme | inhibits

Lagertemp.

−20°C

SMILES String

[H]C(=O)C(CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C(C)C

InChI

1S/C27H44N10O6/c1-16(2)21(23(40)34-18(15-38)10-6-12-32-25(28)29)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17/h3-5,8-9,15-16,18-21H,6-7,10-14H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)/t18?,19-,20-,21-/m0/s1

InChIKey

SDNYTAYICBFYFH-KTYMLHDXSA-N

Allgemeine Beschreibung

Chemical structure: peptide

Biochem./physiol. Wirkung

Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Einheitendefinition

1 U entspricht der Inhibitormenge, welche die Trypsinaktivität um 1 BAEE-U reduziert. (1 BAEE-U ist die Enzymmenge, die bei 253 nm eine Extinktionszunahme von 0.001 pro Minute bei pH 7.6 und 25°C bewirkt; BAEE, Fluka®-Nr. 12880, als Substrat)

Sonstige Hinweise

Protease inhibitor

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Leupeptin -hemisulfat (Salz) BioUltra, microbial, ≥95% (HPLC)

Sigma-Aldrich

L5793

Leupeptin -hemisulfat (Salz)

Benzamidin ≥95.0%

Sigma-Aldrich

12072

Benzamidin

3,4-Dichlorisocumarin serine protease inhibitor

Sigma-Aldrich

D7910

3,4-Dichlorisocumarin

Pepstatin A ≥100,000 U/mg

Sigma-Aldrich

77170

Pepstatin A

E-64 protease inhibitor

Sigma-Aldrich

E3132

E-64

Pepstatin A from Streptomyces species

Roche

PEPS-RO

Pepstatin A

Pepstatin A microbial, ≥75% (HPLC)

Sigma-Aldrich

P4265

Pepstatin A

Catherine Gaitanaki et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 13(3), 173-180 (2003-07-24)
To examine whether the calpain-calpastatin system is activated during the calcium paradox in the isolated perfused pigeon heart, we separated the protease from its inhibitor calpastatin and studied its kinetic properties. The protease exhibits kinetic properties similar to those of
Tanya V Kogan et al.
The Journal of infectious diseases, 189(11), 1965-1973 (2004-05-15)
Aspergillus fumigatus is an opportunistic pathogenic fungus that predominantly infects the respiratory system. Penetration of the lung alveolar epithelium is a key step in the infectious process. The cytoskeleton of alveolar epithelial cells forms the cellular basis for the formation
E S Johnson et al.
The Journal of cell biology, 147(5), 981-994 (1999-12-01)
SUMO is a ubiquitin-related protein that functions as a posttranslational modification on other proteins. SUMO conjugation is essential for viability in Saccharomyces cerevisiae and is required for entry into mitosis. We have found that SUMO is attached to the septins
Raquel Alves Dos Santos et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(2), 671-677 (2007-10-27)
The use of antioxidants during chemotherapy has been shown to reduce or prevent the undesirable effects experienced by healthy cells. Micronutrient selenium is well known for its antioxidant properties; however, selenium exhibits a bimodal nature in that both its beneficial
André L S Santos et al.
International journal for parasitology, 36(1), 47-56 (2005-11-29)
In this study, we report the ultrastructural and growth alterations caused by cysteine peptidase inhibitors on the plant trypanosomatid Phytomonas serpens. We showed that the cysteine peptidase inhibitors at 10 microM were able to arrest cellular growth as well as
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