Y0001466

Wasserfreies Docetaxel

European Pharmacopoeia (EP) Reference Standard

• Synonym(e): Docetaxel
• Empirische Formel (Hill-System): C₄₃H₅₃NO₁₄
• CAS-Nummer: 114977-28-5
• Molekulargewicht: 807.88
• MDL-Nummer: MFCD00800737
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329831437
• NACRES: NA.24

Eigenschaften

• Qualität: pharmaceutical primary standard
• API-Familie: docetaxel
• Hersteller/Markenname: EDQM
• mp (Schmelzpunkt): 186-192 °C (dec.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: [H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c6ccccc6
• InChI: 1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
• InChIKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
• Angaben zum Gen: human ... TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)

Beschreibung

Allgemeine Beschreibung

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Anwendung

Anhydrous Docetaxel EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem./physiol. Wirkung

Docetaxel ist ein mit Paclitaxel verwandter anti-Krebs Wirkstoff und gehört zur Familie der Taxane. Es bindet und stabilisiert die β−Tubulin Untereinheit der Mikortubuli und verhindert dadurch die Depolymerisierung der mitotischen Spindel; daduch blockiert es den Zellzuklus und führt im Weiteren zur Apoptose.

Verpackung

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Sonstige Hinweise

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS07,GHS08
• Signalwort: Danger
• H-Sätze: H315 - H319 - H341 - H360D - H362 - H372
• P-Sätze: P202 - P260 - P263 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Lact. - Muta. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1
• Lagerklassenschlüssel: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable