PHR2932

Rosiglitazon

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 5-[[4-[2-(Methyl-2-pyridinamino)ethoxy]phenyl]methyl]-2,4-thiazolidindion
• Lineare Formel: C₁₈H₁₉N₃O₃S
• CAS-Nummer: 122320-73-4
• Molekulargewicht: 357.43
• MDL-Nummer: MFCD00871760
• UNSPSC-Code: 41116107
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to USP 1605817
• API-Familie: rosiglitazone
• Form: solid
• Verpackung: pkg of 300 mg
• Anwendung(en): pharmaceutical small molecule
• Lagertemp.: 2-8°C
• SMILES String: CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3
• InChI: 1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
• InChIKey: YASAKCUCGLMORW-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Rosiglitazon ist ein starker Agonist für PPARγ mit einer EC50 von 43 nM für den menschlichen Rezeptor. Es ist ein Antidiabetikum, das als Insulin-Sensitizer wirkt, indem es an die PPARγ-Rezeptoren in Fettzellen bindet. Dadurch werden die Zellen reaktionsfähiger gegenüber Insulin.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable