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Merck

PHR1319

Supelco

Trichlorethylen

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

TCE, Trichlorethen

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About This Item

Lineare Formel:
ClCH=CCl2
CAS-Nummer:
Molekulargewicht:
131.39
Beilstein:
1736782
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1601827

Dampfdichte

4.5 (vs air)

Dampfdruck

61 mmHg ( 20 °C)

Analysenzertifikat (CofA)

current certificate can be downloaded

Selbstzündungstemp.

770 °F

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Brechungsindex

n20/D 1.476 (lit.)

bp

86.7 °C (lit.)

mp (Schmelzpunkt)

−84.8 °C (lit.)

Dichte

1.463 g/mL at 25 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

single component solution

Lagertemp.

2-30°C

SMILES String

Cl\C=C(\Cl)Cl

InChI

1S/C2HCl3/c3-1-2(4)5/h1H

InChIKey

XSTXAVWGXDQKEL-UHFFFAOYSA-N

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Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent - Trichloroethylene belongs to the group of class 2 residual solvents. The use of class 2 solvents should be limited in drug substances, excipients, dietary ingredients, and official products because of the inherent toxicities of these residual solvents. Trichloroethylene is a volatile and chlorinated organic compound, which finds applications as a solvent and greasing agent.

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAA0678 in the slot below. This is an example certificate only and may not be the lot that you receive.

Piktogramme

Health hazard

Signalwort

Danger

H-Sätze

Gefahreneinstufungen

Carc. 1B

Lagerklassenschlüssel

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

188.6 °F - closed cup

Flammpunkt (°C)

87 °C - closed cup


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Analysenzertifikate (COA)

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Kunden haben sich ebenfalls angesehen

Yih-Horng Shiao
Environmental and molecular mutagenesis, 50(1), 68-77 (2008-11-26)
Trichloroethylene (TCE), an organic solvent commonly used for metal degreasing and as a chemical additive, is a significant environmental contaminant that poses health concerns in humans. The US Environmental Protection Agency (EPA) is currently revising the 2001 TCE human risk
Jane C Caldwell et al.
Environmental and molecular mutagenesis, 49(2), 142-154 (2007-11-02)
The mode(s) of action (MOA) of a pollutant for adverse health effects may be dependent on the mixture of metabolites resulting from exposure to a single agent and may also be affected by coexposure to pollutants that have similar targets
Cheryl Siegel Scott et al.
International journal of environmental research and public health, 8(11), 4238-4272 (2011-12-14)
We conducted a meta-analysis focusing on studies with high potential for trichloroethylene (TCE) exposure to provide quantitative evaluations of the evidence for associations between TCE exposure and kidney, liver, and non-Hodgkin lymphoma (NHL) cancers. A systematic review documenting essential design
Jane C Caldwell et al.
Environmental health perspectives, 114(9), 1457-1463 (2006-09-13)
Trichloroethylene (TCE) exposure has been associated with increased risk of liver and kidney cancer in both laboratory animal and epidemiologic studies. The U.S. Environmental Protection Agency 2001 draft TCE risk assessment concluded that it is difficult to determine which TCE
Berit Bakke et al.
Journal of occupational and environmental hygiene, 4(5), 375-390 (2007-04-25)
This article describes a systematic review of the industrial hygiene literature for uses of trichloroethylene (TCE) in industry for the exposure assessment of two population-based case control studies of brain cancer in the United States. Papers and reports that address

Protokolle

GC Analysis of Class 2 Residual Solvents on OVI-G43

US EPA Method TO-17: GC Analysis of Volatiles on VOCOL® after Collection/Desorption using Air Toxics Tube

US EPA Method 8260: GC Analysis of Volatiles on SPB®-624 after Purge & Trap using "K" Trap, Fast GC Analysis

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