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Merck

PHR1317

Supelco

Toluene

Residual Solvent, Pharmaceutical Secondary Standard, Certified Reference Material

Synonym(e):

Toluene

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About This Item

Lineare Formel:
C6H5CH3
CAS-Nummer:
Molekulargewicht:
92.14
Beilstein:
635760
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

product name

Toluol, Pharmaceutical Secondary Standard; Certified Reference Material

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1601805

Dampfdichte

3.2 (vs air)

Dampfdruck

22 mmHg ( 20 °C)
26 mmHg ( 25 °C)

Analysenzertifikat (CofA)

current certificate can be downloaded

Selbstzündungstemp.

997 °F

Expl.-Gr.

7 %

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Brechungsindex

n/D 1.496 (lit.)

bp

110-111 °C (lit.)

mp (Schmelzpunkt)

-93 °C (lit.)

Dichte

0.865 g/mL at 25 °C (lit.)

Anwendung(en)

pharmaceutical (small molecule)

Format

single component solution

Lagertemp.

2-30°C

SMILES String

Cc1ccccc1

InChI

1S/C7H8/c1-7-5-3-2-4-6-7/h2-6H,1H3

InChIKey

YXFVVABEGXRONW-UHFFFAOYSA-N

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Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Residual Solvent – Toluene is a certified reference material for the screening and quantification of residual solvents. This CRM is a secondary pharmaceutical reference standard and is traceable and qualified against the corresponding pharmacopeial standards.

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC1709 in the slot below. This is an example certificate only and may not be the lot that you receive.

Signalwort

Danger

Gefahreneinstufungen

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

Zielorgane

Central nervous system

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 3

Flammpunkt (°F)

39.9 °F - closed cup

Flammpunkt (°C)

4.4 °C - closed cup


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Analysenzertifikate (COA)

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Christopher M Filley et al.
Journal of neuropathology and experimental neurology, 63(1), 1-12 (2004-01-30)
In recent decades the organic solvent toluene (methylbenzene) has emerged as one of the best-studied neurotoxins. Long-term and intense exposure to toluene vapors in humans who abuse spray paint and related substances has led to the recognition that toluene has
Murat Yücel et al.
Neuroscience and biobehavioral reviews, 32(5), 910-926 (2008-05-06)
Organic solvent abuse is associated with increased risk for serious medical, neurological, and neuropsychological impairments. While animal research suggests that exposure to organic solvents (especially toluene) may be neurotoxic, much less is known about the consequences of long-term exposure in
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