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Merck

PHR1074

Supelco

Oxybenzon

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(e):

2-Hydroxy-4-Methoxybenzophenon, Oxybenzon

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About This Item

Lineare Formel:
HOC6H3(OCH3)COC6H5
CAS-Nummer:
Molekulargewicht:
228.24
Beilstein:
1913145
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
eCl@ss:
39023842
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

certified reference material
pharmaceutical secondary standard

Qualitätsniveau

Agentur

traceable to USP 1485001

API-Familie

oxybenzone

Analysenzertifikat (CofA)

current certificate can be downloaded

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

bp

150-160 °C/5 mmHg (lit.)

mp (Schmelzpunkt)

62-64 °C (lit.)

Anwendung(en)

environmental
pharmaceutical (small molecule)

Format

neat

Lagertemp.

2-30°C

SMILES String

COc1ccc(c(O)c1)C(=O)c2ccccc2

InChI

1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3

InChIKey

DXGLGDHPHMLXJC-UHFFFAOYSA-N

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Allgemeine Beschreibung

Oxybenzone, also known as benzophenone-3, belongs to the class of aromatic organic UV filters. It is categorized as an endocrine disruptor chemical (EDC) as it can interfere with the endocrine system. It exhibits estrogenic activity through its interaction with the estrogen receptors alpha (ERα) and beta (ERβ). It is a lipophilic, broad-spectrum sunscreen agent which absorbs ultraviolet B (290−320 nm), some ultraviolet A (320−360 nm), and some ultraviolet C (250−290 nm) radiations. It is widely used as an active compound in commercial sunscreens, creams, lotions, lipsticks, perfumes, shower bath, hair sprays, shampoos, and transparent packing material of products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Anwendung

Oxybenzone may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by spectrophotometric and chromatographic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB3268 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Piktogramme

Environment

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 2

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

212.0 °F - closed cup

Flammpunkt (°C)

100 °C - closed cup


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Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Activation of alpha, beta estrogen, pS2 and AHR receptors by UV filters in MCF-7 cell line
Yazar S and Oztas E
Fresenius Environmental Bulletin, 27, 2110-2117 (2018)
Formulation of a novel oxybenzone-loaded nanostructured lipid carriers (NLCs)
Sanad RA, et al.
Aaps Pharmscitech, 11(4), 1684-1694 (2010)
Efficient flow injection and sequential injection methods for spectrophotometric determination of oxybenzone in sunscreens based on reaction with Ni (II)
Chisvert A, et al.
Fresenius Journal of Analytical Chemistry, 369(7-8), 684-689 (2001)
Simultaneous determination of nine UV filters and four preservatives in suncare products by high-performance liquid chromatography
Kim K, et al.
Journal of Chromatographic Science, 49(7), 554-559 (2011)
Estrogenic activity and reproductive effects of the UV-filter oxybenzone (2-hydroxy-4-methoxyphenyl-methanone) in fish
Coronado M, et al.
Aquatic Toxicology (Amsterdam, Netherlands), 90(3), 182-187 (2008)

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