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Merck

90594

Supelco

Bisdemethoxycurcumin

analytical standard

Synonym(e):

(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadien-3,5-dion, Bisdesmethoxycurcumin, Curcumin III, Didemethoxycurcumin

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About This Item

Empirische Formel (Hill-System):
C19H16O4
CAS-Nummer:
Molekulargewicht:
308.33
Beilstein:
3149384
MDL-Nummer:
UNSPSC-Code:
85151701
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Assay

≥95.0% (HPLC)

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

food and beverages

Format

neat

SMILES String

Oc1ccc(cc1)\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2

InChI

1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+

InChIKey

PREBVFJICNPEKM-YDWXAUTNSA-N

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Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Bioorganic & medicinal chemistry letters, 19(3), 706-709 (2008-12-30)
Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with
P V Leyon et al.
Journal of experimental & clinical cancer research : CR, 22(1), 77-83 (2003-05-03)
In this study, some of the synthetic curcuminoid derivatives are analyzed for their anti-angiogenic activity. Intraperitoneal administration of the compounds tetrahydrocurcumin (THC), salicyl curcumin (SC) and curcuminIII (C-III) reduced the number of tumour directed capillaries induced by injecting B16F-10 melanoma
W Chearwae et al.
Biochemical pharmacology, 68(10), 2043-2052 (2004-10-13)
P-glycoprotein (Pgp, ABCB1) is an ATP-dependent drug efflux pump linked to development of multidrug resistance (MDR) in cancer cells. Previously [Biochem Pharmacol 2002;64:573-82], we reported that a curcumin mixture could modulate both function and expression of Pgp. This study focuses
Ratheesh Mohan et al.
Journal of biochemical and molecular toxicology, e22315-e22315 (2019-02-23)
Alcoholic liver diseases are classified as one of the major reasons for worldwide morbidity and mortality. Curcuminoids exhibit a wide range of pharmacological activities that are beneficial for health, including hepatoprotective effects, but its clinical significance is limited due to

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