GF314

TNF- α Protein, Human Recombinant Animal Free

Tumor necrosis factor alpha (TNF-α), also known as cachectin & TNFSF1A, is the prototypic ligand of the TNF superfamily. Recombinant animal free human TNF-α is manufactured using all non-animal reagents.

• Synonym(e): Tumor Necrosis Factor Alpha, TNFa, TNF-alpha, Cachectin, TNFSF1A
• UNSPSC-Code: 12352202
• eCl@ss: 32160405
• NACRES: NA.77

Eigenschaften

• Rekombinant: expressed in E. coli
• Qualitätsniveau: 100
• Assay: >98% (SDS-PAGE and HPLC)
• Verunreinigungen: <0.1 μg/mg protein endotoxin (<1EU/μg)
• NCBI-Hinterlegungsnummer: NM_000594.2
• UniProt-Hinterlegungsnummer: P01375
• Versandbedingung: dry ice

Beschreibung

Allgemeine Beschreibung

Product Source: E. coli

Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

Spezifität

Cross Reactivty
Cow, Monkey, Mouse, Rat, Sheep

Anwendung

Research Category
Entzündung & Immunologie

Research Sub Category
Wachstumsfaktoren & -rezeptoren

Qualität

Bioactivity assay: The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomyocin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥2 x 107 units/mg.

Physikalische Form

Product is filtered through a 0.2 micron filter before lyophilization.

Recombinant animal free human TNF- α is manufactured using all non-animal reagents

Lagerung und Haltbarkeit

Store at -20°C for up to 6 months from date of receipt.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3