CBL1360
Anti-CD117 Antibody, clone ACK2
clone ACK2, Chemicon®, from rat
Synonym(e):
c-kit, SCF Receptor
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About This Item
UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Empfohlene Produkte
Biologische Quelle
rat
Qualitätsniveau
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
ACK2, monoclonal
Speziesreaktivität
mouse
Hersteller/Markenname
Chemicon®
Methode(n)
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Aufnahme
sample type hematopoietic stem cell(s)
sample type mesenchymal stem cell(s)
Isotyp
IgG2bκ
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... KIT(3815)
Allgemeine Beschreibung
This 145 kDa molecule is a member of the tyrosine kinase receptor family and is expressed by a majority of hematopoietic progenitor cells. The interaction of the mouse c-kit receptor and steel factor promotes proliferation and differentiation of hematopoietic progenitor cells. CD117 is also expressed by mast cells, and plays a role in signaling and activation of these cells.
Spezifität
Specifically recognizes mouse CD117, known as c-kit receptor, stem cell factor receptor and steel factor receptor.
Anwendung
Research Category
Stammzellforschung
Stammzellforschung
Research Sub Category
Hämatopoetische Stammzellen
Mesenchymale Stammzellen
Hämatopoetische Stammzellen
Mesenchymale Stammzellen
Detect CD117 using this Anti-CD117 Antibody, clone ACK2 validated for use in FC, IH, IP, FUNC & WB.
Flow Cytometry: 0.2 μg per 10e6 cells
Immunoprecipitation
Immunohistochemistry (Frozen)
Western blot
Blocking Ligand Binding
Optimal working dilutions must be determined by the end user.
Immunoprecipitation
Immunohistochemistry (Frozen)
Western blot
Blocking Ligand Binding
Optimal working dilutions must be determined by the end user.
Zielbeschreibung
145 kDa
Verlinkung
Replaces: CBL1360P
Physikalische Form
Protein A purified
Format: Purified
The monoclonal is presented in phosphate buffered saline containing 10mM sodium azide.
Lagerung und Haltbarkeit
For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
Hinweis zur Analyse
Control
Skin tissue, normal breast epithelium, melanocytes, mast cells and glial cells
Skin tissue, normal breast epithelium, melanocytes, mast cells and glial cells
Sonstige Hinweise
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Rechtliche Hinweise
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Cheng-Hai Zhang et al.
Nature communications, 7, 11358-11358 (2016-04-23)
Smooth muscle sphincters exhibit basal tone and control passage of contents through organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal incontinence. However, the molecular mechanisms underlying this tone remain unknown. Here, we
L Sha et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 3840-3849 (2010-06-15)
Gastric and small intestinal circular smooth muscle layers have a transwall resting membrane potential (RMP) gradient that is dependent on release of carbon monoxide (CO) from interstitial cells of Cajal (ICCs). Our aim was to determine whether a RMP gradient
S Vincent et al.
Development (Cambridge, England), 125(22), 4585-4593 (1998-10-21)
The Kit receptor and its ligand KL, which together constitute an essential effector at various stages of embryonic development, are both present during adult gametogenesis. In the testis, KL is expressed in Sertoli cells, and Kit in germ cells, starting
Masutaka Tokuda et al.
Biology of reproduction, 76(1), 130-141 (2006-10-13)
In the mammalian testis, spermatogenesis is initiated from a subset of stem cells belonging to undifferentiated type A spermatogonia. In spite of the biologic significance of undifferentiated type A spermatogonia, little is known about their behavior and properties because of
Emily J Poulin et al.
Stem cell research, 13(3 Pt A), 422-430 (2014-12-03)
Lrig1 is an intestinal stem cell marker important for epithelial homeostasis. However, the position of the Lrig1(+) population in the intestinal crypt has been debated, largely due to discrepant staining patterns using two Lrig1 antibodies. Here, we set out to
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