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Key Documents

AB2910

Sigma-Aldrich

Anti-Mcl-1 Antibody

serum, Chemicon®

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

Antikörperform

serum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Speziesreaktivität

human

Hersteller/Markenname

Chemicon®

Methode(n)

immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... MCL1(4170)

Spezifität

Recognizes Human Mcl-1. Not reactive with other members of the Bcl-2 family, as verified by immunoblot.

Immunogen

Synthetic peptide corresponding to amino acids 121-139 of human Mcl-1.

Anwendung

Research Category
Apoptose & Krebs
Research Sub Category
BCL2 & Hemmung
Immunoblot 1:2,000

Immunoprecipitation. Precipitates a 37-39 kDa protein, which appears as a doublet in some cells.

Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

The following tissues/cells can serve as positive controls: tonsil, tonsillar B cells, B-cell lines Reh, Daudi, and Karpas 422.

Optimal working dilutions for AB2910 must be determined by end user.
This Anti-Mcl-1 Antibody is validated for use in IP, WB, IH(P) for the detection of Mcl-1.

Physikalische Form

Liquid antiserum.

Lagerung und Haltbarkeit

Store at -20°C for up to 12 months in undiluted aliquots. Avoid repeated freeze-thaw cycles.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1


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Die Dokumentenbibliothek aufrufen

Yixiang Li et al.
Theranostics, 10(17), 7656-7670 (2020-07-21)
Prostate cancer is the second leading cause of cancer-related death in the United States. As a first line treatment for hormone-refractory prostate cancer, docetaxel (DTX) treatment leads to suboptimal effect since almost all patients eventually develop DTX resistance. In this
Georges Sabra et al.
Experimental cell research, 317(14), 1994-2006 (2011-06-18)
This study reveals that it is possible to obtain a specific cell response towards low-fouling carboxymethyl dextran (CMD) surfaces bearing the RGD adhesive peptide in fibrin. To avoid cell sedimentation on surfaces observed in traditional cell culture systems, CMD surfaces
Nicole M Smith et al.
Journal of neuroinflammation, 15(1), 201-201 (2018-07-10)
Following injury to the central nervous system, increased microglia, secretion of pro- and anti-inflammatory cytokines, and altered blood-brain barrier permeability, a hallmark of degeneration, are observed at and immediately adjacent to the injury site. However, few studies investigate how regions

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