539522

PKC_ε Translocation Inhibitor Peptide

The PKC_ε Translocation Inhibitor Peptide, Negative Control controls the biological activity of PKC_ε. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): PKC_ε Translocation Inhibitor Peptide, Protein Kinase Cε Translocation Inhibitor I, EAVSLKPT, PKCε Translocation Inhibitor I, PKCε-RACK2 Interaction Inhibitor I
• Empirische Formel (Hill-System): C₃₇H₆₅N₉O₁₃
• Molekulargewicht: 843.96
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: lyophilized solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Farbe: white
• Löslichkeit: water: 3 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

An octapeptide that selectively inhibits the translocation of PKC_ε to subcellular sites. Inhibition of PKC_ε translocation is known to specifically block phorbol ester or norepinephrine-mediated regulation of contraction in cardiomyocytes.

An octapeptide that selectively inhibits the translocation of protein kinase C_ε to subcellular sites in a reversible manner. Inhibition of PKC_ε translocation is known to specifically block phorbol ester- or norepinephrine-mediated regulation of contraction in cardiomyocytes.

Biochem./physiol. Wirkung

Cell permeable: no

Primary Target
PKCε Translocation

Product does not compete with ATP.

Reversible: yes

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH

Physikalische Form

Supplied as a trifluoroacetate salt.

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417.
Johnson, J.A., et al. 1996. J. Biol. Chem.271, 24962.

Rechtliche Hinweise

Sold under license of U.S. Patent 5,783,405.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable