528122

PI 3,4-K inhibitor, PIK-93

The PI 3,4-K inhibitor, PIK-93, also referenced under CAS 593960-11-3, controls the biological activity of PI 3,4-K. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonym(e): PI 3,4-K inhibitor, PIK-93, N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide
• Empirische Formel (Hill-System): C₁₄H₁₆ClN₃O₄S₂
• CAS-Nummer: 593960-11-3
• Molekulargewicht: 389.88
• MDL-Nummer: MFCD12922510
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: pale yellow
• Löslichkeit: DMSO: 50 mg/mL, pale yellow
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• SMILES String: ClC1=CC=C(C2=C(C)N=C(NC(C)=O)S2)C=C1S(NCCO)(=O)=O
• InChI: 1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
• InChIKey: JFVNFXCESCXMBC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC₅₀ = 16, 19, 39 and 64 nM for p110γ, PI 4-KIIIβ, p110α and DNA-PK, respectively). Moderately inhibits p110δ, PI 3-KC2β, hsVPS34, ATM, p110β and PI 4-KIIIα (IC₅₀ = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 µM, respectively) with minimal inhibition towards a panel of 36-kinases (IC₅₀ >10 µM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250 nM.

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Miller, S., et al. 2010. Science327, 1638.
Fan, Q.W., et al. 2006. Cancer Cell9, 341.
Toth, B., et al. 2006. J. Biol. Chem.281, 36369.
Knight, Z.A., et al. 2006. Cell125, 733.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable