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N-048

Supelco

(±)-Nicotine-d4 solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirische Formel (Hill-System):
C10H10N2D4
CAS-Nummer:
350818-69-8
Molekulargewicht:
166.26
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

300

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

100 μg/mL in acetonitrile

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

forensics and toxicology

Format

single component solution

Lagertemp.

−20°C

SMILES String

[2H]c1nc([2H])c(c([2H])c1[2H])C2CCCN2C

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/i2D,4D,6D,8D

InChIKey

SNICXCGAKADSCV-MNYIHESISA-N

Allgemeine Beschreibung

A stable-labeled internal standard applicable for use in quantification of nicotine levels for forensic analysis, nicotine testing, clinical and diagnostic testing, urine drug testing or isotope dilution methods by LC/MS or GC/MS. Nicotine is a highly additive tobacco alkaloid associated with numerous health risks such as heart health, mental health and cancer.

Anwendung


  • Standard for metabolic and pharmacokinetic studies: (±)-Nicotine-d₄ solution is extensively used as a stable isotope-labeled standard in metabolic and pharmacokinetic research. It aids in tracing nicotine metabolism and understanding its dynamics within biological systems, crucial for developing targeted therapies in nicotine addiction (Kintz et al., 1998).



Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Piktogramme

FlameExclamation mark
GHS02,GHS07

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

35.6 °F - closed cup

Flammpunkt (°C)

2 °C - closed cup

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Rama Krishna Nimmakayala et al.
Gastroenterology, 155(3), 892-908 (2018-06-05)
Cigarette smoking is a major risk factor for pancreatic cancer. Aggressive pancreatic tumors contain cancer cells with stem cell features. We investigated whether cigarette smoke induces stem cell features in pancreatic cancer cells. KrasG12D; Pdx1-Cre mice were exposed to cigarette

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