M-021

(±)-Methadon-D3 -Lösung

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(e): DL-Methadon-d₃ -Lösung, DL-6-Dimethylamino-4,4-diphenyl-3-heptanon-1,1,1-d₃ -Lösung, DL-Methadon-(heptyl-1,1,1-d₃) -Lösung
• Empirische Formel (Hill-System): C₂₁D₃H₂₄NO
• CAS-Nummer: 60263-63-0
• Molekulargewicht: 312.46
• EG-Nummer: 200-659-6
• MDL-Nummer: MFCD00673285
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329817743
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material
• Qualitätsniveau: 300
• Form: liquid
• Leistungsmerkmale: Snap-N-Spike^®/Snap-N-Shoot^®
• Verpackung: ampule of 1 mL
• Hersteller/Markenname: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• Konzentration: 1.0 mg/mL in methanol
• Methode(n): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Anwendung(en): forensics and toxicology
• Format: single component solution
• Massenverschiebung: M+3
• Lagertemp.: 2-8°C
• SMILES String: [2H]C([2H])([2H])CC(=O)C(CC(C)N(C)C)(c1ccccc1)c2ccccc2
• InChI: 1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/i1D3
• InChIKey: USSIQXCVUWKGNF-FIBGUPNXSA-N

Beschreibung

Allgemeine Beschreibung

Ein stabil markierter interner Standard zur Verwendung in Isotopenverdünnungsverfahren oder zur Quantifikation des Methadongehalts mittels GC/MS oder LC/MS in der forensischen Analytik, Drogentests im Urin, Schmerzmittelüberwachung oder klinischen Toxikologie. Methadon ist ein synthetisches Opioid, das medizinisch als Schmerzmittel und als gegen Sucht wirksames Mittel bei Patienten mit Opioid-Abhängigkeit eingesetzt wird. Das Arzneimittel wird unter verschiedenen Handelsnamen wie Symoron, Dolophine^®, Amidone, Methadose^®, Physeptone oder Heptadon verkauft.

Anwendung

• Opioid pharmacokinetics research: (±)-Methadone-D3 solution is utilized in opioid pharmacokinetics research to track and analyze the metabolism of methadone, providing insights into its pharmacological properties and interaction dynamics (Beck et al., 2010).


• MethaDonemetabolism study: As a deuterated methaDonesolution, it is critical for detailed studies on drug metabolism, aiding in the understanding of methadone′s biotransformation and its implications for therapeutic efficacy and safety (Anggård et al., 1979).


• Mass spectrometry internal standard: Methadone-D3 serves as an internal standard in mass spectrometry, enhancing the precision of quantitative analyses in forensic and clinical toxicology (Johansen and Jensen, 2004).


• Analytical research: Employed in analytical research, Methadone-D3 solution facilitates the development of advanced analytical methods for the detection and quantification of opioids in various biological matrices (Lucas et al., 2000).


• Drug metabolism research: This solution is key in drug metabolism research, helping to identify the metabolic pathways and excretion profiles of methadone, which is crucial for developing effective dosing regimens and understanding drug interactions (Kintz et al., 1998).

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Dolophine is a registered trademark of Roxane Laboratories, Inc.

Methadose is a registered trademark of Mallinckrodt Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H225 - H301 + H311 + H331 - H370
• P-Sätze: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Zielorgane: Eyes
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 1
• Flammpunkt (°F): 49.5 °F - closed cup
• Flammpunkt (°C): 9.7 °C - closed cup