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900407P

Avanti

16:0-pacFA PC

Avanti Research™ - A Croda Brand 900407P, powder

Synonym(e):

1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine

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About This Item

Empirische Formel (Hill-System):
C39H72N3O8P
CAS-Nummer:
2260670-74-2
Molekulargewicht:
741.98
UNSPSC-Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

Form

powder

Verpackung

pkg of 1x10 mg (900407P-10MG)
pkg of 1 × 1 mg (900407P-1mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 900407P

Lipid-Typ

click reagents
phospholipids

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

C#CCCCC1(N=N1)CCCCCCCCC(O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCCCCCC)=O)=O

Allgemeine Beschreibung

The pacFA lipid attached to 1-palmitoyl-sn-glycero-3-phosphocholine, contains a photoactivable diazirine ring with a clickable alkyne group.

Anwendung

1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine (16:0-pacFA PC) might be used to label hydrogenated zwitterionic bicelles (HZB) and hydrogenated anionic bicelles (HAB).

Biochem./physiol. Wirkung

1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine (16:0-pacFA PC) may be used for a global analysis of protein–lipid interactions in living cells. pacFA acts as a precursor for the biosynthesis of bifunctional lipids. Proteins in contact with the bifunctional lipids are then cross-linked by ultraviolet (UV) irradiation of the diazirine ring. Finally, click chemistry is used to label the alkyne with a reporter molecule.

Verpackung

5 mL Amber Glass Screw Cap Vial (900407P-10MG)
5 mL Amber Glass Screw Cap Vial (900407P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Lagerklassenschlüssel

11 - Combustible Solids

Flammpunkt (°F)

No data available

Flammpunkt (°C)

No data available

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Dominique Mias-Lucquin et al.
Journal of structural biology, 209(1), 107411-107411 (2019-11-07)
Dystrophin is a large intracellular protein that prevents sarcolemmal ruptures by providing a mechanical link between the intracellular actin cytoskeleton and the transmembrane dystroglycan complex. Dystrophin deficiency leads to the severe muscle wasting disease Duchenne Muscular Dystrophy and the milder
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.
Per Haberkant et al.
Angewandte Chemie (International ed. in English), 52(14), 4033-4038 (2013-03-02)
Per Haberkant et al.
Biochimica et biophysica acta, 1841(8), 1022-1030 (2014-01-21)
Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as

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