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870602C

Avanti

PGPC

Avanti Research™ - A Croda Brand 870602C

Synonym(e):

1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine

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About This Item

Empirische Formel (Hill-System):
C29H56NO10P
CAS-Nummer:
89947-79-5
Molekulargewicht:
609.73
UNSPSC-Code:
12352211
NACRES:
NA.25

Form

liquid

Verpackung

pkg of 1 × 1 mL (870602C-1mg)
pkg of 1 × 1 mL (870602C-5mg)

Hersteller/Markenname

Avanti Research™ - A Croda Brand 870602C

Konzentration

1 mg/mL (870602C-1mg)
5 mg/mL (870602C-5mg)

Lipid-Typ

phospholipids
phosphoglycerides

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O

Anwendung

PGPC (1-palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine) may be used as a standard in mass spectrometry analysis of phospholipids and oxidized phospholipids.

Biochem./physiol. Wirkung

1-palmitoyl-2-glutaroyl-sn-glycero-phosphocholine (PGPC) is a truncated oxidized phospholipid (Tr-OxPL). It elicits endothelial barrier disruption. PGPC exhibits proinflammatory properties and increases the production of protective enzyme such as heme oxygenase 1. It acts as a precursor for the synthesis of 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphoethanolamine (PGPE). PGPC stimulates apoptotic signaling in vascular smooth muscle cells (VSMCs).

Verpackung

5 mL Clear Glass Sealed Ampule (870602C-1mg)
5 mL Clear Glass Sealed Ampule (870602C-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Zielorgane

Liver,Kidney, Respiratory system

Lagerklassenschlüssel

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

does not flash

Flammpunkt (°C)

does not flash

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Alexandra Moumtzi et al.
Journal of lipid research, 48(3), 565-582 (2006-12-01)
Lipid oxidation is now thought to be an initiating and sustaining event in atherogenesis. Oxidatively fragmented phospholipids, namely 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), present in minimally modified LDL and atherosclerotic lesions, have been reported to elicit a wide range of
Mario Brameshuber et al.
Biophysical journal, 110(1), 205-213 (2016-01-09)
We previously developed a single-molecule microscopy method termed TOCCSL (thinning out clusters while conserving stoichiometry of labeling), which allows for direct imaging of stable nanoscopic platforms with raft-like properties diffusing in the plasma membrane. As a consensus raft marker, we
Marco Di Gioia et al.
Nature immunology, 21(1), 42-53 (2019-11-27)
Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns (DAMPs) induce inflammatory gene expression. However

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