860516P

C16 Ceramide (d18:1/16:0)

Avanti Research^™ - A Croda Brand

• Synonym(e): N-palmitoyl-D-erythro-sphingosine
• Empirische Formel (Hill-System): C₃₄H₆₇NO₃
• CAS-Nummer: 24696-26-2
• Molekulargewicht: 537.90
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 10 mg (860516P-10mg); pkg of 1 × 100 mg (860516P-100mg); pkg of 1 × 25 mg (860516P-25mg); pkg of 1 × 5 mg (860516P-5mg); pkg of 1 × 50 mg (860516P-50mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C34H67NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-33,36-37H,3-26,28,30-31H2,1-2H3,(H,35,38)/b29-27+/t32-,33+/m0/s1
• InChIKey: YDNKGFDKKRUKPY-TURZORIXSA-N

Beschreibung

Allgemeine Beschreibung

Ceramide comprise sphingosine and fatty acid and belongs to the sphingolipids family.

Anwendung

C16 Ceramide (d18:1/16:0) has been used:

• as an internal standard in the chromatography with negative ion electrospray ionization coupled to tandem mass spectrometry for myocardial ceramide quantification
• as an internal standard for the ceramide quantification from rat samples using liquid chromatography-mass spectrometry
• to test its effect on mitochondrial stress response in worms

Biochem./physiol. Wirkung

C16 Ceramide levels are elevated in chronic alcohol-related liver disease (ALD). In general, ceramide inhibits mitochondrial function and insulin signaling. They are essential component of cell membrane and are involved in lipid raft formation. C16 ceramide based analog (C2-C16 CCPS) is potential anticancer agent used in chemotherapy. The levels of C16 ceramide and its ratio with other ceramides is regarded as a biomarker in predicting coronary artery disease (CAD). It interacts with the DNA-binding domain of tumor suppressor protein p53 and activates p53.

Verpackung

5 mL Amber Glass Screw Cap Vial (860516P-100mg)

5 mL Amber Glass Screw Cap Vial (860516P-10mg)

5 mL Amber Glass Screw Cap Vial (860516P-25mg)

5 mL Amber Glass Screw Cap Vial (860516P-50mg)

5 mL Amber Glass Screw Cap Vial (860516P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable