934283

4-(Aminoethyl)-1-N-Boc-piperidine

≥95.0%

• Synonym(e): 1-tert-Butoxycarbonyl-4-piperidineethanamine, 2-(N-tert-Butoxycarbonyl-4-piperidinyl)ethylamine
• Empirische Formel (Hill-System): C₁₂H₂₄N₂O₂
• CAS-Nummer: 146093-46-1
• Molekulargewicht: 228.33
• MDL-Nummer: MFCD04038459
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95.0%
• Form: semisolid
• Farbe: off-white to light yellow
• Lagertemp.: 2-8°C
• SMILES String: O=C(OC(C)(C)C)N1CCC(CCN)CC1
• InChI: 1S/C12H24N2O2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9,13H2,1-3H3
• InChIKey: LBQDLHPFISVBRU-UHFFFAOYSA-N

Beschreibung

Anwendung

A semi-flexible linker useful for PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of PROTACs may impact degradation kinetics as well as drug design (absorption; distribution; metabolism; excretion; and toxicity; ADMET) properties of PROTACs.

Technology Spotlight:

Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Sonstige Hinweise

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Rechtliche Hinweise

PROTAC^® is a registered trademark of Arvinas Operations; Inc.; and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable