930792

3-[1,3-Dihydro-4-(4-hydroxy-1-butyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione

≥95.0%

• Synonym(e): 2,6-Piperidinedione, 3-[1,3-dihydro-4-(4-hydroxy-1-butyn-1-yl)-1-oxo-2H-isoindol-2-yl]
• Empirische Formel (Hill-System): C₁₇H₁₆N₂O₄
• CAS-Nummer: 2207541-23-7
• Molekulargewicht: 312.32
• MDL-Nummer: MFCD32903468
• UNSPSC-Code: 12352101
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95.0%
• Form: powder
• Funktionelle Gruppe: hydroxyl
• Lagertemp.: 2-8°C
• SMILES String: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(C#CCCO)C3C2)CC1

Beschreibung

Anwendung

3-[1,3-Dihydro-4-(4-hydroxy-1-butyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione is a functionalized cereblon (CRBN) ligand used in the development of lenalidomide-based protein degrader building blocks. Can be activated by many nucleophiles or form ether linkages through its terminal hydroxyl group. A basic building block for development of a protein degrader library.

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Sonstige Hinweise

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Impact of linker length on the activity of PROTACs

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360D
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable