766917

Lithium-bis-(trimethylsilyl)-amid -Lösung

1.5 M in THF

• Synonym(e): Hexamethyldisilazan Lithiumsalz
• Lineare Formel: [(CH₃)₃Si]₂NLi
• CAS-Nummer: 4039-32-1
• Molekulargewicht: 167.33
• Beilstein: 3567910
• MDL-Nummer: MFCD00008261
• UNSPSC-Code: 12352111
• PubChem Substanz-ID: 329767270
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Qualitätsniveau: 100
• Konzentration: 1.5 M in THF
• Dichte: 0.893 g/mL at 25 °C
• SMILES String: [Li]N([Si](C)(C)C)[Si](C)(C)C
• InChI: 1S/C6H18NSi2.Li/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
• InChIKey: YNESATAKKCNGOF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Lithium bis(trimethylsilyl)amide is commonly used in organic synthesis as a non-nucleophilic strong Bronsted base. It is soluble in most nonpolar solvents such as aromatic hydrocarbons, hexanes, and THF.

Anwendung

Lithium bis(trimethylsilyl)amide can be used as a reagent:     

• In the deprotonation and nucleophilic difluoromethylation reactions.
• 3-methoxy substituted dihydropyrrole derivatives by reacting with aldehydes and lithiated methoxyallene via in situ formations of N-trimethylsilylated imines.  
• In Darzens condensation and directed aldol condensation reactions.      
• To synthesize poly(N-octyl-p-benzamide)s by chain-growth polycondensation of 4-octylaminobenzoic acid methyl ester.

Sicherheitshinweise

• Piktogramme: GHS02,GHS08,GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H225,H251,H314,H335,H336,H351
• P-Sätze: P210 - P235 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Self-heat. 1 - Skin Corr. 1B - STOT SE 3
• Zielorgane: Central nervous system, Respiratory system
• Zusätzliche Gefahrenhinweise: EUH014,EUH019
• Lagerklassenschlüssel: 4.2 - Pyrophoric and self-heating hazardous materials
• WGK: WGK 2
• Flammpunkt (°F): 31.3 °F - closed cup
• Flammpunkt (°C): -0.4 °C - closed cup