756482

P(t-Bu)₃ Pd G2

• Synonym(e): Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)] palladium(II)
• Empirische Formel (Hill-System): C₂₄H₃₇ClNPPd
• CAS-Nummer: 1375325-71-5
• Molekulargewicht: 512.40
• MDL-Nummer: MFCD21608496
• UNSPSC-Code: 12161600
• PubChem Substanz-ID: 329766544
• NACRES: NA.22

Eigenschaften

• Form: solid
• Qualitätsniveau: 100
• Leistungsmerkmale: generation 2
• Eignung der Reaktion: core: palladium; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reaction type: Heck Reaction; reaction type: Hiyama Coupling; reaction type: Negishi Coupling; reaction type: Sonogashira Coupling; reaction type: Stille Coupling; reaction type: Suzuki-Miyaura Coupling; reagent type: catalyst; reaction type: Cross Couplings
• mp (Schmelzpunkt): 167-170 °C (decomposition)
• Funktionelle Gruppe: phosphine
• SMILES String: NC1=C(C2=CC=CC=C2[Pd]Cl)C=CC=C1.CC(C)(C)P(C(C)(C)C)C(C)(C)C
• InChI: 1S/C12H10N.C12H27P.ClH.Pd/c13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-10(2,3)13(11(4,5)6)12(7,8)9;;/h1-6,8-9H,13H2;1-9H3;1H;/q;;;+1/p-1
• InChIKey: ZVSLIOFJVMRWHJ-UHFFFAOYSA-M

Beschreibung

Allgemeine Beschreibung

P(t-Bu)₃ Pd G2 (Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)] palladium(II)) is a second generation (G2) precatalyst containing a biphenyl-based ligand. Product participates in various palladium catalyzed cross-coupling reactions, C-C, C-N and C-O bond formation reactions, and Suzuki-Miyaura coupling reactions. It generates active Pd catalyst at room temperature in the presence of weak phosphate or carbonate bases. It has been proposed as an active catalyst for use in Stille reactions of aryl halides (bromides and chlorides).

Anwendung

P(t-Bu)₃ Pd G2 (Chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)] palladium(II), Pd/P(t-Bu)₃) may be used as catalyst in the following studies:

• Synthesis of sterically hindered biaryls (tetra-ortho-substituted), via cross-coupling reactions of aryl chlorides.
• Stille cross-couplings reactions of aryl chloride.
• Synthesis of chloropeptin I, via Stille cross-coupling reaction.
• Heck reaction.
• Negishi cross-coupling reactions.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable