677191

(R)-(+)-α,α-Diphenyl-2-Pyrrolidin-Methanoltrimethylsilylether

96%

• Synonym(e): (2R)-2-[Diphenyl-[(trimethylsilyl)-oxy]-methyl]-pyrrolidin, (R)-α,α-Diphenylprolinol-trimethylsilylether, (R)-2-[Diphenyl-(trimethylsilanyloxy)-methyl]-pyrrolidin
• Empirische Formel (Hill-System): C₂₀H₂₇NOSi
• CAS-Nummer: 943757-71-9
• Molekulargewicht: 325.52
• MDL-Nummer: MFCD09265100
• UNSPSC-Code: 12352005
• PubChem Substanz-ID: 24885355
• NACRES: NA.22

Eigenschaften

• Assay: 96%
• Form: solid
• Optische Aktivität: [α]22/D +52±5°, c = 1 in chloroform
• Brechungsindex: n20/D 1.5509
• Dichte: 1.0459 g/mL at 25 °C
• Funktionelle Gruppe: phenyl
• Lagertemp.: 2-8°C
• SMILES String: C[Si](C)(C)OC([C@H]1CCCN1)(c2ccccc2)c3ccccc3
• InChI: 1S/C20H27NOSi/c1-23(2,3)22-20(19-15-10-16-21-19,17-11-6-4-7-12-17)18-13-8-5-9-14-18/h4-9,11-14,19,21H,10,15-16H2,1-3H3/t19-/m1/s1
• InChIKey: RSUHWMSTWSSNOW-LJQANCHMSA-N

Beschreibung

Allgemeine Beschreibung

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether is a diarylprolinol silyl ether organocatalyst.

Anwendung

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether can be used as a catalyst to synthesize:

• Glycofused tricyclic derivatives, which are used in the development of amyloid β-peptide diagnostic tools.
• Cyclohexene carbaldehyde derivatives by reacting benzoylnitromethane with aliphatic enals.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves