377953

2-Chlor-2-oxo-1,3,2-dioxaphospholan

• Synonym(e): 2-Chlor-1,3,2-dioxaphospholan-2-oxid, Ethylen-cycl.-chlorphosphat
• Empirische Formel (Hill-System): C₂H₄ClO₃P
• CAS-Nummer: 6609-64-9
• Molekulargewicht: 142.48
• Beilstein: 606582
• EG-Nummer: 229-560-6
• MDL-Nummer: MFCD00043138
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24863533
• NACRES: NA.22

Eigenschaften

• Form: liquid
• Verunreinigungen: <10% 2-Chloro-1,3,2-dioxaphospholane
• Brechungsindex: n20/D 1.45 (lit.)
• bp: 89-91 °C/0.8 mmHg (lit.)
• mp (Schmelzpunkt): 12-14 °C (neat) (lit.)
• Dichte: 1.55 g/mL at 25 °C (lit.)
• Lagertemp.: −20°C
• SMILES String: ClP1(=O)OCCO1
• InChI: 1S/C2H4ClO3P/c3-7(4)5-1-2-6-7/h1-2H2
• InChIKey: SBMUNILHNJLMBF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen .

2-Chloro-1,3,2-dioxaphospholane 2-oxide is used in esterification reactions for cyclic phosphate synthesis, also reacts with phenyl grignard reagents.

Anwendung

Phosphorylating agent used in the syntheses of phosphatidylcholines.

Reactant for:

• Synthesis of amino-functionalized hybrid hydrocarbon/fluorocarbon double-chain phospholipid
• Synthesis of UV-polymerizable lipids via Chabrier reaction
• Syntheses of block copolymers of poly(aliphatic ester) with clickable polyphosphoester
• Imprinting molecular recognition sites on multiwalled carbon nanotubes surface for electrochemical detection of insulin in real samples
• Synthesis of a zwitterionic silane
• Synthesis of a core-shell-corona micelle stabilized by reversible cross-linkage for intracellular drug delivery

Sicherheitshinweise

• Piktogramme: GHS05
• Signalwort: Danger
• H-Sätze: H314
• P-Sätze: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Gefahreneinstufungen: Eye Dam. 1 - Skin Corr. 1B
• Zusätzliche Gefahrenhinweise: EUH014,EUH029
• Lagerklassenschlüssel: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): >235.4 °F - closed cup
• Flammpunkt (°C): > 113 °C - closed cup
• Persönliche Schutzausrüstung: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter