SRP8054

Tim-1 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• Synonyme(s) : Hepatitis A virus cellular receptor 1, KIM1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin and mucin domain-containing protein 4, TIMD1
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: human
• Produit recombinant: expressed in CHO cells
• Pureté: ≥98% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: monomer 57 kDa by calculation
• Conditionnement: pkg of 100 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Impuretés: <0.06 EU/μg endotoxin, tested
• Couleur: white
• Numéro d'accès UniProt: Q96D42
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... HAVCR1(26762)

Description

Description générale

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

Forme physique

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstitution

Reconstitute at 100 μg/mL in sterile PBS.

Autres remarques

The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable