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SRP3240

Sigma-Aldrich

GRO/KC (CXCL1) from rat

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Synonyme(s) :

CINC, CXCL1, GRO?, NAP-3

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Source biologique

rat

Produit recombinant

expressed in E. coli

Pureté

≥98% (HPLC)
≥98% (SDS-PAGE)

Forme

lyophilized

Puissance

10.0-100.0 ng/mL

Poids mol.

7.8 kDa

Conditionnement

pkg of 25 μg

Technique(s)

cell culture | mammalian: suitable

Impuretés

<0.1 EU/μg endotoxin, tested

Couleur

white to off-white

Numéro d'accès UniProt

P14095

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

rat ... CXCL1(81503)

Catégories apparentées

Description générale

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat KC is a 7.8 kDa protein consisting of 72 amino acids including the ‘ELR′ motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Actions biochimiques/physiologiques

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. Recombinant rat KC is a 7.8 kDa protein consisting of 72 amino acids including the ‘ELR′ motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Séquence

APVANELRCQ CLQTVAGIHF KNIQSLKVMP PGPHCTQTEV IATLKNGREA CLDPEAPMVQ KIVQKMLKGV PK

Forme physique

Lyophilized with no additives.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

GRO: a novel chemotactic cytokine.
R Sager et al.
Advances in experimental medicine and biology, 305, 73-77 (1991-01-01)
P Tekamp-Olson et al.
The Journal of experimental medicine, 172(3), 911-919 (1990-09-01)
A cDNA clone of murine macrophage inflammatory protein 2 (MIP-2) has been isolated from a library prepared from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the nucleotide sequence determined. This cDNA was used to clone cDNAs for human homologues of MIP-2
S Haskill et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(19), 7732-7736 (1990-10-01)
The product of the human GRO gene is a cytokine with inflammatory and growth-regulatory properties; GRO is also called MGSA for melanoma growth-stimulatory activity. We have identified two additional genes, GRO beta and GRO gamma, that share 90% and 86%

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