SRP2081
Retinoblastoma protein human
recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
Synonyme(s) :
OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma 1
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.26
Produits recommandés
Source biologique
human
Produit recombinant
expressed in insect cells
Pureté
≥70% (SDS-PAGE)
Forme
frozen liquid
Poids mol.
~107.5 kDa
Conditionnement
pkg of 5 μg
Conditions de stockage
avoid repeated freeze/thaw cycles
Concentration
400 μg/mL
Couleur
clear colorless
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−70°C
Informations sur le gène
human ... RB1(5925)
Description générale
The gene encoding retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.
Actions biochimiques/physiologiques
pRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of the E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-Myc, c-Fos through the binding with E2F factors and thereby regulating cell proliferation.
Forme physique
Clear and colorless frozen liquid solution
Notes préparatoires
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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W H Lee et al.
Science (New York, N.Y.), 235(4794), 1394-1399 (1987-03-13)
Recent evidence indicates the existence of a genetic locus in chromosome region 13q14 that confers susceptibility to retinoblastoma, a cancer of the eye in children. A gene encoding a messenger RNA (mRNA) of 4.6 kilobases (kb), located in the proximity
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma.
S H Friend et al.
Nature, 323(6089), 643-646 (1986-10-16)
The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that their effects can be observed when they are introduced into non-malignant cells. There is evidence for another class of oncogenes, in which tumour-predisposing mutations are recessive
Z Onadim et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(13), 6177-6181 (1992-07-01)
The retinoblastoma-predisposition gene, RB1, segregates as an autosomal dominant trait with high (90%) penetrance. Certain families, however, show an unusual low-penetrance phenotype with many individuals being unaffected, unilaterally affected, or with evidence of spontaneously regressed tumors. We have used single-strand
Thao T Le et al.
Chemical science, 11(17), 4467-4474 (2020-04-21)
Although RNA aptamers can show comparable or better specificity and affinity to antibodies and have the advantage of being able to access different live cell compartments, they are often much less stable in vivo. We report here the first aptamer
Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL).
Lens D
Leukemia, 14(3), 427-430 (2000)
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