SML2556

Pt-ttpy

>97% (NMR)

• Synonyme(s) : (SP-4-2)-Chloro[4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine-κN1,κN1′,κN1′′]-Platinum(1+) chloride, Tolylterpyridin-platin
• Formule empirique (notation de Hill) : C₂₂H₁₇Cl₂N₃Pt
• Numéro CAS: 727721-37-1
• Poids moléculaire : 589.37
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: >97% (NMR)
• Forme: powder
• Couleur: faint yellow to dark orange
• Solubilité: DMSO: 0.2 mg/mL (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1=CC=C(C2=CC(C3=[N+]4C=CC=C3)=[N+]5C(C6=CC=CC=[N+]6[Pt-2]54Cl)=C2)C=C1.[Cl-]
• InChI: 1S/C22H17N3.2ClH.Pt/c1-16-8-10-17(11-9-16)18-14-21(19-6-2-4-12-23-19)25-22(15-18)20-7-3-5-13-24-20;;;/h2-15H,1H3;2*1H;/q;;;+2/p-2
• Clé InChI: UWAUJHRZLKCPPX-UHFFFAOYSA-L

Description

Actions biochimiques/physiologiques

G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells

Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable