SML1277

Geldanamycin-FITC

≥98% (HPLC), from Streptomyces hygroscopicus

• Synonyme(s) : Geldanamycin, fluorescein isothiocyanate labeled
• Formule empirique (notation de Hill): C₅₅H₆₃N₅O₁₃S
• Poids moléculaire : 1034.18
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: Streptomyces hygroscopicus
• Niveau de qualité: 200
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: yellow to yellow-orange
• Solubilité: DMSO: soluble 5 mg/mL
• Spectre d'activité de l'antibiotique: neoplastics
• Mode d’action: enzyme | inhibits
• Température de stockage: −20°C

Description

Description générale

Chemical structure: benzenoid

Actions biochimiques/physiologiques

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines. Geldanamycin binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation of proteins and the cellular stress response. In addition, Geldanamycin is a potent inhibitor of the nuclear hormone receptor family.

Geldanamycin-FITC is a fluorescent derivative of geldanamycin. It is used as a fluorescent tracer for heat shock protein 90 (HSP90) inhibitors in fluorescence polarization (FP) competition binding assay.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable