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Key Documents

SAB4504690

Sigma-Aldrich

Anti-phospho-Bax (pSer184) antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 21 kDa

Espèces réactives

mouse, rat, human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100

Numéro d'accès NCBI

Q07812

Numéro d'accès UniProt

Q07812

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

phosphorylation (pSer184)

Informations sur le gène

human ... BAX(581)

Description générale

Bif-1 (BAX-interacting factor 1), a membrane-curvature inducing protein is located on human chromosome 19q13. Bif-1 is also known as SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)/ Endophilin B1. It belongs to the membrane curvature-driving endophilin protein family.

Immunogène

The antiserum was produced against synthesized peptide derived from human Bax around the phosphorylation site of Ser184.

Immunogen Range: 143-192

Actions biochimiques/physiologiques

Bif-1 (BAX-interacting factor 1) plays a vital role in apoptosis. BAX gene may act as a negative regulator of autophagy in CRC (Colorectal cancer) development. Lack of Bif-1 affects lipid homeostasis and results in obesity followed by insulin resistance.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

The BAX gene as a candidate for negative autophagy-related genes regulator on mRNA levels in colorectal cancer.
Gil J, et al.
Medical Oncology (Northwood, London, England), 34(2), 16-16 (2017)
The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria.
Simonyan L, et al.
Biochimica et Biophysica Acta - Biomembranes, 1859(6), 1144-1155 (2017)
Wnt signal transduction pathway and apoptosis: a review.
Pecina-Slaus N
Cancer Cell International, 10(1), 22-22 (2010)
Won-Kyu Ju et al.
Oxidative medicine and cellular longevity, 2020, 9410289-9410289 (2020-10-22)
[This corrects the article DOI: 10.1155/2019/8060962.].
Ying Liu et al.
Scientific reports, 6, 20453-20453 (2016-02-10)
Bif-1 is a membrane-curvature inducing protein that is implicated in the regulation of autophagy and tumorigenesis. Here, we report that Bif-1 plays a critical role in regulating lipid catabolism to control the size of lipid droplets and prevent the development

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