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SAB4501470

Sigma-Aldrich

Anti-5-HT-1B antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

5-HT-1B, 5-HT-1D-β, 5-HT1B, 5-hydroxytryptamine receptor 1B, Serotonin receptor 1B

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 43 kDa

Espèces réactives

human, mouse, rat

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

Numéro d'accès NCBI

P28222

Numéro d'accès UniProt

P28222

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HTR1B(3351)

Description générale

5-HT-1B/HTR1B (5-hydroxytryptamine receptor 1B) is a presynaptic and postsynaptic receptor, present in the basal ganglia, hippocampus and cortex. It is located on human chromosome 6q14.1.
Anti-5-HT-1B Antibody detects endogenous levels of total 5-HT-1B protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human 5-HT-1B.

Immunogen Range: 201-250

Actions biochimiques/physiologiques

5-HT-1B/HTR1B (5-hydroxytryptamine receptor 1B) plays an important role in locomotion, feeding and thermoregulation and also in arterial contractile regulation mechanisms. It participates in regulating the effects of serotonin.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression.
Duan J, et al.
Molecular Psychiatry, 8(11), 901-910 (2003)
Katsura Nozawa et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(9), 3408-3413 (2009-02-13)
Serotonin (5-hydroxytryptamine; 5-HT) is abundantly present throughout the gastrointestinal tract and stored mostly in enterochromaffin (EC) cells, which are located on the mucosal surface. 5-HT released from EC cells stimulate both intrinsic and extrinsic nerves, which results in various physiological
Nadja Osterberg et al.
Cell and tissue research, 336(1), 11-20 (2009-02-19)
Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanisms underlying the differentiation of

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