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Key Documents

SAB4500488

Sigma-Aldrich

Anti-PARP (Cleaved-Gly215) antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

ADP-ribosyltransferase 1, ADPRT, ADPRT1, PARP, pADPRT-1

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 89 kDa

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:1000
western blot: 1:500-1:1000

Numéro d'accès NCBI

P09874

Numéro d'accès UniProt

P09874

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

proteolytically cleaved (Gly215)

Informations sur le gène

human ... PARP1(142)

Description générale

Anti-PARP (Cleaved-Gly215) Antibody detects endogenous levels of fragment of activated PARP (Cleaved-Gly215) protein.

Immunogène

The antiserum was produced against synthesized peptide derived from human PARP.

Immunogen Range: 196-245

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Lijun Wang et al.
The journal of gene medicine, 22(12), e3254-e3254 (2020-07-18)
Non-small cell lung cancer (NSCLC) is a lethal tumor resulting in a large number of cancer-related deaths globally. Long noncoding RNAs (lncRNAs) may modulate tumor initiation and metastasis. Although dysregulation of lncRNA cancer susceptibility 19 (CASC19) is validated in NSCLC
Lijun Wang et al.
The journal of gene medicine, 22(12), e3254-e3254 (2020-07-18)
Non-small cell lung cancer (NSCLC) is a lethal tumor resulting in a large number of cancer-related deaths globally. Long noncoding RNAs (lncRNAs) may modulate tumor initiation and metastasis. Although dysregulation of lncRNA cancer susceptibility 19 (CASC19) is validated in NSCLC
Shaohua Chen et al.
Cancer letters, 348(1-2), 20-28 (2014-02-19)
In this study, we explored the antitumor activities of the PARP inhibitor AZD2281 (Olaparib) and the pan-Bcl-2 inhibitor GX15-070 (Obatoclax) in six pancreatic cancer cell lines. While both agents were able to cause growth arrest and limited apoptosis, the combination
François Lamoureux et al.
European urology, 66(1), 145-155 (2014-01-15)
Although prostate cancer responds initially to androgen ablation therapies, progression to castration-resistant prostate cancer (CRPC) frequently occurs. Heat shock protein (Hsp) 90 inhibition is a rational therapeutic strategy for CRPC that targets key proteins such as androgen receptor (AR) and
Makiko Yamashita et al.
Human molecular genetics, 23(16), 4345-4356 (2014-04-05)
TAR DNA-binding protein of 43 kDa (TDP-43) is the major component protein of inclusions found in brains of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). However, the molecular mechanisms by which TDP-43 causes neuronal dysfunction and
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