SAB2900334
Anti-HSP90AA1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
heat shock protein hsp 90-alpha, hsp 86, hsp90a, hspc1, hspca
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
human, rat, mouse, chicken, monkey, Drosophila
Technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: suitable
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... HSP90AA1(3320)
Description générale
Heat shock protein 90 (Hsp90α) gene is mapped to human chromosome 14q32.31. Hsp90α is an isoform of Hsp90 and is a cytoplasmic protein that comprises three domains, namely C-terminal, middle domain, and N-terminal nucleotide-binding domain. This protein is associated with membrane microdomains and lipid rafts.
Immunogène
Synthetic peptide from human HSP90AA1 / Hsp90.
Application
Anti-HSP90AA1 antibody produced in rabbit has been used in immunohistochemistry at a dilution of 1:400.
Actions biochimiques/physiologiques
Heat shock protein 90 alpha family class A member 1 (HSP90AA1 or Hsp90α) is upregulated during stress and helps in survival from membrane stress, especially during drug targeting. It elicits cytoprotective function and mediates protein homeostasis in the cytoplasm. An elevated level of Hsp90α is observed during chronic obstructive pulmonary disease (COPD). Hsp90α also favors spermatocyte maturation and human ether-a-go-go-related gene (hERG) ion channel maturation.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Keiichi Koshizuka et al.
Auris, nasus, larynx, 45(4), 854-865 (2017-12-14)
Our recent studies have revealed that both strands of pre-miRNAs, the guide strand and the passenger strand, are involved in cancer pathogenesis. Analyses of miRNA expression signatures by RNA sequencing in head and neck squamous cell carcinoma (HNSCC) showed that
Abbey D Zuehlke et al.
Gene, 570(1), 8-16 (2015-06-14)
Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid
Hui-Yu Chen et al.
Veterinary parasitology, 205(3-4), 540-550 (2014-10-02)
Anisakid nematodes are distributed worldwide in a wide variety of marine fishes and they are known to cause the zoonotic disease, anisakiasis. The temperature control is commonly applied for prevention and control of anisakiasis. To analyze the cellular response to
Balázs Rada et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 63(10), 821-830 (2014-07-23)
We studied the involvement of calcium and calcium-activated NADPH oxidases in NLRP3 inflammasome activation and IL-1β release to better understand inflammasome signaling in macrophages. Human volunteer blood donors were recruited to isolate monocytes to differentiate them into macrophages. Wild-type or
Xin Zhao et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(11), 1079-1089 (2014-08-12)
Arsenic trioxide (As2O3) is used to treat acute promyelocytic leukemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the human ether-a-go-go-related gene (hERG) current via disturbing its trafficking to cellular
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