SAB2701683
Anti-th antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonyme(s) :
th, tyrosine hydroxylase
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Espèces réactives
zebrafish
Technique(s)
western blot: 1:500-1:3000
Numéro d'accès NCBI
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
zebrafish ... th(30384)
Description générale
Tyrosine hydroxylase (TH) is a cytoplasmic enzyme. The TH gene codes for a monooxygenase.
Immunogène
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 111 and 450 of th according to NP_571224
Application
Anti-th antibody produced in rabbit has been used in:
- western blotting (1:1000)
- whole retinal flat-mount immunolabelling (1:500)
- immunofluorescence (2:1000)
- immunohistochemistry (2:1000)
Actions biochimiques/physiologiques
Cell surface-associated protein is implicated in virulence. Promotes bacterial attachment exclusively to the γ-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus.
Tyrosine hydroxylase (TH), the rate-limiting enzyme of dopamine synthesis, is essential for catecholamine biosynthesis. Its major role is to catalyze the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA). TH mainly serves as marker furcate cholaminergic neurons. Missense mutations in the TH gene are associated with Segawa′s syndrome, L-DOPA responsive infantile Parkinsonism, or L-DOPA responsive dystonia (DRD).
Caractéristiques et avantages
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Forme physique
1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Aquatic Chronic 3 - Skin Sens. 1
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Soundhar Ramasamy et al.
The Journal of experimental biology, 222(Pt 1) (2018-11-18)
High fecundity, transparent embryos for monitoring the rapid development of organs and the availability of a well-annotated genome has made zebrafish a model organism of choice for developmental biology and neurobiology. This vertebrate model, which is also a favourite in
Chen Zhu et al.
Fitoterapia, 117, 47-51 (2017-01-09)
In this study, to study the effect of rhynchophylline on TH in midbrain of methamphetamine-induced conditioned place preference (CPP) adult zebrafish, place preference adult zebrafish models were established by methamphetamine (40μg/g) and the expression of TH was observed by immunohistochemistry
Dong-Jun Lv et al.
Behavioural brain research, 372, 112031-112031 (2019-06-14)
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the world. Apart from motor deficits, PD reduces patient's quality of life through sleep disturbances, cognitive impairment and emotional disorders. However, it's unclear whether bad life habits such as
Constance Pierre et al.
The Journal of experimental biology, 223(Pt 18) (2020-08-02)
The neurotransmitter serotonin controls a variety of physiological and behavioral processes. In humans, mutations affecting monoamine oxidase (MAO), the serotonin-degrading enzyme, are highly deleterious. Yet, blind cavefish of the species Astyanax mexicanus carry a partial loss-of-function mutation in MAO (P106L)
Ilaria Gregorio et al.
Disease models & mechanisms, 15(9) (2022-08-11)
Mutations of genes coding for collagen VI (COL6) cause muscle diseases, including Ullrich congenital muscular dystrophy and Bethlem myopathy. Although COL6 genetic variants were recently linked to brain pathologies, the impact of COL6 deficiency in brain function is still largely
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