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S6936

Sigma-Aldrich

Anti-Sodium Channel, Pan antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti-SP19

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About This Item

Numéro MDL:
MFCD02097413
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

rat

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:200-1:600

Numéro d'accès UniProt

P04774

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

rat ... Scn1a(81574)

Description générale

Voltage-gated sodium channels (VGSC) are membrane proteins that are usually present in excitable cells. These sodium channels regulate neurological functions such as the generation of action potentials in nerve cells. Alterations in neurological sodium ion channels have been associated with epilepsy, whereas mutations in cardiac sodium channels have been linked to long QT syndrome . Anti-Sodium Channel, Pan antibody is specific for the α subunit of VGSC in rats.

Immunogène

synthetic peptide corresponding to amino acids 1491-1508 of the α subunit of rat type I voltage-gated sodium channel (VGSC, SP19) (with additional C-terminal cysteine). The epitope corresponds to the sequence in the intracellular loop between the III and IV domains of the VGSC α subunit.This epitope is identical in vertebrates, and highly homologous in mollusks and insects.

Application

Anti-Sodium Channel, Pan antibody is suitable for use in immunohistochemistry (formalin-fixed, paraffin-embedded sections), immunoprecipitation and chemiluminescent western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H302 + H332,H311,H412

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Megan Oliva et al.
Epilepsia, 53(11), 1849-1859 (2012-08-22)
Voltage-gated sodium channels (VGSCs) are integral membrane proteins. They are essential for normal neurologic function and are, currently, the most common recognized cause of genetic epilepsy. This review summarizes the neurobiology of VGSCs, their association with different epilepsy syndromes, and
Verena C Wimmer et al.
The Journal of physiology, 588(Pt 11), 1829-1840 (2010-04-09)
The axon initial segment (AIS) contains the site of action potential initiation and plays a major role in neuronal excitability. AIS function relies on high concentrations of different ion channels and complex regulatory mechanisms that orchestrate molecular microarchitecture. We review
I Vabnick et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 16(16), 4914-4922 (1996-08-15)
The distribution of Na+ channels in rat peripheral nerve was measured during development by using immunofluorescence. Small segments of sciatic nerve from postnatal day 0-13 (P0-P13) pups were labeled with an antibody raised against a well conserved region of the
G M Vincent et al.
Cardiology in review, 7(1), 44-55 (1999-06-01)
The inherited long QT syndrome is caused by mutations of at least 5 ion channel genes. Mutations of the cardiac sodium ion channel gene and 3 potassium channel genes have been identified to this time. A genetic locus on chromosome
X Liu et al.
Respiratory physiology & neurobiology, 178(3), 362-369 (2011-03-15)
Experiments in recent years have revealed labile electrophysiological and neurochemical phenotypes in primary afferent neurons exposed to specific stimulus conditions associated with the development of chronic pain. These studies collectively demonstrate that the mechanisms responsible for functional plasticity are primarily
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