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P8692

Sigma-Aldrich

Paromomycin sulfate salt

powder, suitable for plant cell culture, BioReagent

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About This Item

Formule empirique (notation de Hill):
C23H45N5O14 · xH2SO4
Numéro CAS:
1263-89-4
Poids moléculaire :
615.63 (free base basis)
Numéro Beilstein :
5715182
Code UNSPSC :
10171502
ID de substance PubChem :
24898967
Nomenclature NACRES :
NA.72

product name

Paromomycin sulfate salt, suitable for plant cell culture, BioReagent

Gamme de produits

BioReagent

Niveau de qualité

200

Forme

powder

Technique(s)

cell culture | plant: suitable

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria

Application(s)

agriculture

Mode d’action

protein synthesis | interferes

Chaîne SMILES 

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

Clé InChI

OYJABWUHUYVDMJ-UDXJMMFXSA-N

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Catégories apparentées

Description générale

Chemical structure: aminoglycoside

Application

Paromomycin, monomycin, is an aminoglycoside antibiotic used to select genetically transformed plants and plant cells.

Actions biochimiques/physiologiques

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Conditionnement

5g,25g

Autres remarques

Keep container tightly closed in a dry and well-ventilated place

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Kazuki Saito et al.
Nucleic acids research, 43(9), 4591-4601 (2015-04-22)
In eukaryotes, the tRNA-mimicking polypeptide-chain release factor, eRF1, decodes stop codons on the ribosome in a complex with eRF3; this complex exhibits striking structural similarity to the tRNA-eEF1A-GTP complex. Although amino acid residues or motifs of eRF1 that are critical
Takahiko Akematsu et al.
iScience, 23(1), 100749-100749 (2019-12-31)
During sexual reproduction in the ciliate, Tetrahymena thermophila, cells of complementary mating type pair ("conjugate") undergo simultaneous meiosis and fertilize each other. In both mating partners only one of the four meiotic products is "selected" to escape autophagy, and this
Sarah Hendrickx et al.
PLoS neglected tropical diseases, 6(5), e1664-e1664 (2012-06-06)
Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in India. Although no clinical resistance has yet been reported, proactive vigilance should be warranted. The present in vitro study compared the outcome and stability of experimental PMM-resistance induction
Joline Goossens et al.
Toxins, 4(4), 281-295 (2012-05-19)
It is recognized that mycotoxins can cause a variety of adverse health effects in animals, including altered gastrointestinal barrier function. It is the aim of the present study to determine whether mycotoxin-contaminated diets can alter the oral bioavailability of the
Vasundhra Bhandari et al.
PLoS neglected tropical diseases, 6(5), e1657-e1657 (2012-05-26)
With widespread resistance to antimonials in Visceral Leishmaniasis (VL) in the Indian subcontinent, Miltefosine (MIL) has been introduced as the first line therapy. Surveillance of MIL susceptibility in natural populations of Leishmania donovani is vital to preserve it and support
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Articles

Antibiotic Kill Curve

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

Antibiotic Kill Curve

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

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