K1632
Kininogen high molecular weight, Two Chain from human plasma
lyophilized powder
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About This Item
Produits recommandés
Source biologique
human plasma
Niveau de qualité
Forme
lyophilized powder
Solubilité
H2O: soluble 0.1 mg protein/mL
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... KNG1(3827) , KNG1 (includes EG:3827)
Description générale
HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.
Actions biochimiques/physiologiques
High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.
High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.
Conditionnement
Package size based on protein content
Forme physique
Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl
Notes préparatoires
Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
Certificats d'analyse (COA)
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Henri Weidmann et al.
Biochimica et biophysica acta. Molecular cell research, 1864(11 Pt B), 2118-2127 (2017-07-27)
The contact system is a potent procoagulant and proinflammatory plasma protease cascade that is initiated by binding ("contact")-induced, auto-activation of factor XII zymogen. Formed active serine protease FXIIa then cleaves plasma prekallikrein to kallikrein that in turn liberates the mediator
[Omeprazole long-term therapy: how great is the risk of developing a carcinoid tumor?].
H Koop
Zeitschrift fur Gastroenterologie, 26(12), 769-771 (1988-12-01)
Rince John et al.
FEBS letters, 591(21), 3507-3522 (2017-09-28)
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