H139

HA-1077 dihydrochloride

solid, ≥98% (HPLC)

• Synonyme(s) : 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
• Formule empirique (notation de Hill): C₁₄H₁₇N₃O₂S · 2HCl
• Numéro CAS: 203911-27-7
• Poids moléculaire : 364.29
• Numéro MDL: MFCD00153805
• Code UNSPSC : 12352200
• ID de substance PubChem : 24895456
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: H₂O: >10 mg/mL
• Chaîne SMILES: Cl[H].Cl[H].O=S(=O)(N1CCCNCC1)c2cccc3cnccc23
• InChI: 1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
• Clé InChI: NOXXIYDYFSNHDF-UHFFFAOYSA-N

Description

Application

HA-1077 dihydrochloride has been used:

• to relax cantilevers
• in the functional assessment of isolated coronary arteries
• to investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV)

Actions biochimiques/physiologiques

HA-1077/fasudil, is a Rho kinase inhibitor. This ROCK inhibitor has the ability to increase cognitive deficits in animals, that have Alzheimer′s disease (AD). In humans, fasudil possesses high therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH). HA-1077 also acts as an inhibitor of protein kinases, like myosin light chain kinase and Rho associated kinase. Hence, it can block myosin phosphorylation.

Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca²⁺ antagonist.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)