Accéder au contenu
MilliporeSigma
Toutes les photos(3)

Principaux documents

G9002

Sigma-Aldrich

Guanosine 5′-triphosphate tris salt

≥93% (HPLC), powder

Synonyme(s) :

GTP

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme


About This Item

Formule empirique (notation de Hill):
C10H16N5O14P3 · 3 C4H11NO3
Numéro CAS:
Poids moléculaire :
886.59
Numéro MDL:
Code UNSPSC :
41106305
ID de substance PubChem :
Nomenclature NACRES :
NA.51

Source biologique

Porcine brain
bacterial (corynebacterium sp)
bovine (casein)
yeast

Niveau de qualité

Essai

≥93% (HPLC)

Forme

powder

Couleur

white

Solubilité

H2O: soluble 50 mg/mL, clear to slightly hazy, colorless

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

NC(CO)(CO)CO.NC(CO)(CO)CO.NC(CO)(CO)CO.NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.3C4H11NO3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;3*5-4(1-6,2-7)3-8/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);3*6-8H,1-3,5H2/t3-,5-,6-,9-;;;/m1.../s1

Clé InChI

UXNOYHQEVMMTDK-CYCLDIHTSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Guanosine 5′-triphosphate (GTP) is a molecule rich in energy.

Application

GTP from Sigma was used
  • in a study to induce dissociation of the endogenous neuropeptide galanin from its binding sites prior to incubation with radiolabeled ligand
  • as a substrate along with FtsZ in a colorimetric assay to detect GTPase activity to test polymerization of FtsZ, the prokaryotic ortholog of tubulin, in the absence of Na+
  • as a pipette solution for patch-clamp Ca2+ measurements in a study
  • as an internal standard during the analysis of water-soluble inositol phosphate

Actions biochimiques/physiologiques

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
The extracellular guanosine 5′-triphosphate (GTP) acts as an enhancer of myogenic cell differentiation. It plays a key role in miRNA-myogenic regulator factor modulation. It also participates in the release of exosome stuffed with guanosine and guanosine-based molecules secretion. GTP is considered as an activated precursor for RNA synthesis. It also plays a major role in the synthesis and localization of protein, signal transduction, visual excitation and hormone action.
The translocation of proteins into the mitochondria matrix involves the interactions of both GTP and ATP. These imported proteins are important in several pathways regulated in mitochondria. GTP is involved in the initiation of peptide synthesis during the binding of formylmethionyl-tRNA (F-met-tRNA) to the ribosome. It is also involved in polypeptide chain elongation. GTP is hydrolyzed by tubulin and its hydrolysis is accompanied by microtubule assembly.

Notes préparatoires

Prepared from Catalog No. G8877.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

GTP (Guanosine Triphosphate)
Encyclopedia of Genetics, 900-901 (2001)
Leo R Quinlan
Methods in molecular biology (Clifton, N.J.), 329, 127-149 (2006-07-19)
The stimulation of inositol phospholipid metabolism via phospholipase C (PLC) is an important signal transduction pathway in a wide variety of cell types. Activation of the pathway is associated with many aspects of cellular activity, including cell growth and differentiation.
Jesús Mendieta et al.
Journal of molecular biology, 390(1), 17-25 (2009-05-19)
Bacterial cell division occurs through the formation of a protein ring (division ring) at the site of division, with FtsZ being its main component in most bacteria. FtsZ is the prokaryotic ortholog of eukaryotic tubulin; it shares GTPase activity properties
B Planas et al.
Neuroendocrinology, 61(6), 646-654 (1995-06-01)
The neuropeptide galanin (GAL) has been implicated in a variety of neuroendocrine functions and has been shown to be regulated by gonadal hormones in several brain regions. We have used slice binding and quantitative autoradiography techniques to determine whether the
Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine
Pietrangelo T, et al.
Frontiers in Pharmacology, 9 (2018)

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique