F9803

FTI-277 trifluoroacetate salt

≥95% (HPLC), film

• Synonyme(s) : N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt
• Formule empirique (notation de Hill): C₂₂H₂₉N₃O₃S₂ · xC₂HF₃O₂
• Numéro CAS: 170006-73-2
• Poids moléculaire : 447.61 (free base basis)
• Numéro MDL: MFCD06795840
• Code UNSPSC : 51111800
• ID de substance PubChem : 329799790
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: film
• Conditions de stockage: desiccated
• Solubilité: H₂O: ≥2 mg/mL
• Conditions d'expédition: dry ice
• Température de stockage: −70°C
• Chaîne SMILES: OC(=O)C(F)(F)F.COC(=O)[C@H](CCSC)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2ccccc2
• InChI: 1S/C22H29N3O3S2.C2HF3O2/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);(H,6,7)/t16-,20+;/m1./s1
• Clé InChI: GJEFFRDWFVSCOJ-PXPMWPIZSA-N

Description

Application

Farnesyltransferase inhibitor 277 (FTI-277) has been used to:

• inhibit protein farnesylation in breast cell lines.
• in marrow-isolated adult multilineage inducible cells (MIAMI).
• inhibition of farnesyl transferase in CV-1 in Origin with SV40 genes cells (COS-7).

Actions biochimiques/physiologiques

Farnesyltransferase inhibitor 277 (FTI-277) mediates apoptosis in multiple myeloma and is regarded as a potential therapeutic agent.

Highly potent (pM/nM) Ras CAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. Inhibitor of farnesyltransferase (Ftase) IC₅₀ = 50 nM.

Conditionnement

Very hygroscopic material, package in a dry room with deoxygenated MeOH and pump down the solvent. Store with desiccant.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves