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F7876

Sigma-Aldrich

Folic acid

≥97%

Synonyme(s) :

PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Formule empirique (notation de Hill):
C19H19N7O6
Numéro CAS:
59-30-3
Poids moléculaire :
441.40
Numéro Beilstein :
100781
Numéro CE :
200-419-0
Numéro MDL:
MFCD00079305
Code UNSPSC :
12352106
eCl@ss :
34058014
ID de substance PubChem :
57654192
Nomenclature NACRES :
NA.79

Source biologique

synthetic (organic)

Pureté

≥97%

Forme

powder

Technique(s)

HPLC: suitable

Couleur

faint orange to dark orange-yellow
faint yellow to dark yellow

Pf

>285 °C

Température de stockage

room temp

Chaîne SMILES 

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

Clé InChI

OVBPIULPVIDEAO-LBPRGKRZSA-N

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Catégories apparentées

Application

Folic acid has been used:
  • to induce acute kidney injury in mice
  • as a supplement to cultivate MCF-7 breast cancer cells.
  • to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Actions biochimiques/physiologiques

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.
Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Romain Froquet et al.
Nature protocols, 4(1), 25-30 (2009-01-10)
Dictyostelium amoebae have been used as a host model to measure virulence of a wide range of bacterial pathogens. The simple protocol described here takes advantage of the ability of Dictyostelium to grow and form plaques on a lawn of
Surface-enhanced Raman spectroscopy of cell lysates mixed with silver nanoparticles for tumor classification.
Hassoun M, et al.
Beilstein Journal of Nanotechnology, 8, 1183-1183 (2017)
Novel water-borne polyurethane nanomicelles for cancer chemotherapy: higher efficiency of folate receptors than TRAIL receptors in a Cancerous Balb/C Mouse Model.
Ajorlou E, et al.
Pharmaceutical Research, 33(6), 1426-1439 (2016)
Fibroblast Growth Factor 23 Expression is increased in Multiple Organs in Mice with Folic Acid-induced Acute Kidney Injury.
Egli-Spichtig D, et al.
Frontiers in Physiology, 9, 1494-1494 (2018)
Silvia Ferrè et al.
Kidney international, 96(6), 1359-1373 (2019-10-12)
Sepsis is a systemic inflammatory state in response to infection, and concomitant acute kidney injury (AKI) increases mortality significantly. Endoplasmic reticulum stress is activated in many cell types upon microbial infection and modulates inflammation. The role of endoplasmic reticulum signaling
Afficher tous les articles scientifiques apparentés

Articles

Folic Acid Metabolism in Cancer

This issue of Biofiles reviews some of our newest and most innovative technologies and their specific applications toward cancer research. In preparing this issue of Biofiles, one is reminded how complex the disease of cancer is, and how difficult it is to identify one topic that is completely unrelated to any other.

Folic Acid Metabolism: A Role in Cancer's Cause and Cure

This article reviews some of our newest and most innovative technologies and their specific applications toward cancer research. It describes how complex the disease of cancer is, and how difficult it is to identify one topic that is completely unrelated to any other.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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