Accéder au contenu
MilliporeSigma
Toutes les photos(1)

Key Documents

View All Documentation

D4297

Sigma-Aldrich

Deoxycholic acid

BioXtra, ≥98% (HPLC)

Synonyme(s) :

3α,12α-Dihydroxy-5β-cholanic acid, 7-Deoxycholic acid, Desoxycholic acid

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C24H40O4
Numéro CAS:
83-44-3
Poids moléculaire :
392.57
Numéro Beilstein :
3219882
Numéro CE :
201-478-5
Numéro MDL:
MFCD00003673
Code UNSPSC :
12161900
ID de substance PubChem :
24893857

Source biologique

bovine bile (ex gall bladder)

Description

anionic

Gamme de produits

BioXtra

Pureté

≥98% (HPLC)

Forme

powder

Poids mol.

micellar avg mol wt 1200-5000

Nombre d'agrégation

3-12

Impuretés

≤0.005% Phosphorus (P)
≤0.1% Insoluble matter

Résidus de calcination

≤0.1%

CMC

2-6

Pf

171-174 °C (lit.)

Traces de cations

Al: ≤0.001%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.005%
K: ≤0.005%
Mg: ≤0.005%
NH4+: ≤0.05%
Na: ≤0.02%
Pb: ≤0.001%
Zn: ≤0.0005%

HLB

16

Groupe fonctionnel

carboxylic acid

Conditions d'expédition

ambient

Température de stockage

room temp

Chaîne SMILES 

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

Clé InChI

KXGVEGMKQFWNSR-LLQZFEROSA-N

Informations sur le gène

human ... ATIC(471)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Description générale

Deoxycholic acid is a bile acid that may affect intracellular signaling and gene expression.

Application

Deoxycholic acid has been used in a study to assess how physiological concentrations of ursodeoxycholic acid (UDCA) vs. deoxycholic acid (DCA) affect barrier function in mouse intestinal tissue. It has also been used in a study to characterize bile formation in a mouse model with hepatic disruption of the cytochrome p450 (CYP) oxidoreductase gene.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H315,H319,H335

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Les clients ont également consulté

Slide 1 of 5

1 of 5

Désoxycholate de sodium

SAFC

S1827

Désoxycholate de sodium

Ursodeoxycholic acid British Pharmacopoeia (BP) Reference Standard

BP706

Ursodeoxycholic acid

Désoxycholate de sodium BioXtra, ≥98.0% (dry matter, NT)

Sigma-Aldrich

30970

Désoxycholate de sodium

Cholic acid United States Pharmacopeia (USP) Reference Standard

USP

1133503

Cholic acid

Cholic acid European Pharmacopoeia (EP) Reference Standard

C2158000

Cholic acid

Ying Kong et al.
The international journal of biochemistry & cell biology, 44(12), 2321-2332 (2012-08-21)
There is evidence indicating that bile acid is a promoter of colorectal cancer. Deoxycholic acid modifies apoptosis and proliferation by affecting intracellular signaling and gene expression. We are interested in revealing the relationship between deregulated miRNAs and deoxycholic acid in
Cindy Kunne et al.
Hepatology (Baltimore, Md.), 57(4), 1509-1517 (2012-11-28)
The difference in bile salt (BS) composition between rodents and humans is mainly caused by formation of muricholate in rodents as well as by efficient rehydroxylation of deoxycholic acid. The aim of this study was to characterize bile formation in
J Stadler et al.
Cancer letters, 38(3), 315-320 (1988-01-01)
Rectal biopsies and fecal collections were obtained from a consecutive series of 34 outpatients prior to colonoscopy at a gastroenterology clinic. Subsequently, 14 were found to have no colonic pathology, 13 had adenomatous polyps, (3 of those had a previous
Kunihiko Nishino et al.
Antimicrobial agents and chemotherapy, 54(5), 2239-2243 (2010-03-10)
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps
Jeffery L Smith et al.
Hepatology (Baltimore, Md.), 39(6), 1673-1682 (2004-06-09)
Focal biliary cirrhosis causes significant morbidity and mortality in cystic fibrosis (CF). Although the mechanisms of pathogenesis remain unclear, bile acids have been proposed as potential mediators of liver injury. This study examined bile acid composition in CF and assessed
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique