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C6506

Sigma-Aldrich

4-Chloro-DL-phenylalanine

greener alternative

Synonyme(s) :

PCP, PCPA

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About This Item

Formule linéaire :
ClC6H4CH2CH(NH2)CO2H
Numéro CAS:
7424-00-2
Poids moléculaire :
199.63
Numéro CE :
231-051-9
Numéro MDL:
MFCD00002601
Code UNSPSC :
12352209
ID de substance PubChem :
24278081
Nomenclature NACRES :
NA.32

Forme

solid

Score du produit alternatif plus écologique

old score: 2
new score: 1
Find out more about DOZN™ Scoring

Caractéristiques du produit alternatif plus écologique

Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Pf

>240 °C (dec.) (lit.)

Autre catégorie plus écologique

, Re-engineered

Température de stockage

room temp

Chaîne SMILES 

NC(Cc1ccc(Cl)cc1)C(O)=O

InChI

1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

Clé InChI

NIGWMJHCCYYCSF-UHFFFAOYSA-N

Informations sur le gène

human ... TPH1(7166) , TPH2(121278)

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Catégories apparentées

Description générale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.

Application

4-Chloro-DL-phenylalanine has been used:
  • as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
  • to induce insomnia in rat models
  • used to treat embryos to examine its effect on serotonin
  • for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
  • to feed flies to explore serotonin effect

Actions biochimiques/physiologiques

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
Tryptophan hydroxylase inhibitor.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301,H317

Classification des risques

Acute Tox. 3 Oral - Skin Sens. 1

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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