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B9688

Sigma-Aldrich

Pizotifen

≥98% (HPLC)

Synonyme(s) :

Pizotifen, Pizotyline; 4-(9,10-Dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thien-4-ylidene)-1-methylpiperidine

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About This Item

Formule empirique (notation de Hill):
C19H21NS
Numéro CAS:
15574-96-6
Poids moléculaire :
295.44
Numéro CE :
239-632-9
Numéro MDL:
MFCD00864192
Code UNSPSC :
12352200
ID de substance PubChem :
329773323
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

powder

Solubilité

DMSO: ≥8 mg/mL

Auteur

Novartis

Température de stockage

room temp

Chaîne SMILES 

CN1CCC(\CC1)=C2\c3ccccc3CCc4sccc24

InChI

1S/C19H21NS/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18/h2-5,10,13H,6-9,11-12H2,1H3

Clé InChI

FIADGNVRKBPQEU-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Pizotifen is a serotonin antagonist acting mainly at the 5-HT1, 5-HT2A and 5HT2C receptors with some antihistamine activity. It is used for the prevention of vascular headache including migraine and cluster headache.

Caractéristiques et avantages

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H361

Classification des risques

Acute Tox. 4 Oral - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Paul Silcocks et al.
Trials, 11, 71-71 (2010-06-18)
A recent Cochrane Review demonstrated the remarkable lack of reliable clinical trials of migraine treatments for children, especially for the two most prescribed preventative treatments in the UK, Propranolol and Pizotifen.Migraine trials in both children and adults have high placebo
M H Guillet et al.
Annales de dermatologie et de venereologie, 122(11-12), 777-779 (1995-01-01)
Primary erythermalgia is a rare acrosyndrome due to paroxystic arteriolar dilatation of extremities that become red and congested with warmth and burning sensation or pain. We report herein the observation of a primary erythermalgia affecting 3 degrees in the same
Arthur T Strachan et al.
Medicine and science in sports and exercise, 37(3), 389-394 (2005-03-03)
The effect of serotonin (5-HT)2C receptor blockade on the thermal response and exercise performance during exercise in a warm environment was examined. Seven endurance-trained, but not heat-acclimatized, individuals (six males and one female) performed two 40-km time trials on a
G L Briars et al.
Archives of disease in childhood, 93(7), 590-593 (2008-04-03)
To describe the characteristics of weight gain occurring in children treated for migranous conditions with pizotifen Retrospective case note review West Suffolk Hospital between 1999 and 2003 PATIENTS: 405 clinic attendances of 121 children receiving pizotifen treatment Rates of change
Tomasz Huć et al.
Pharmacological research, 130, 172-179 (2017-12-31)
Arterial blood pressure (BP) is regulated by a complex network of peripheral and central (brain) mechanisms. Research suggests that gut bacteria-derived compounds may affect the circulatory system. We evaluated hemodynamic effects of indole, a gut bacteria-derived product of tryptophan, and
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