Accéder au contenu
MilliporeSigma
Toutes les photos(1)

Documents

A1075

Sigma-Aldrich

Amyloid β Protein Fragment 1-40

≥90% (HPLC), powder

Synonyme(s) :

Aβ40

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C194H295N53O58S
Numéro CAS:
131438-79-4
Poids moléculaire :
4329.80
Numéro MDL:
MFCD00130509
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32

Niveau de qualité

200

Pureté

≥90% (HPLC)

Forme

powder

Couleur

white

Solubilité

1% acetic acid: 1 mg/mL
saline: insoluble

Numéro d'accès UniProt

P05067

Température de stockage

−20°C

Informations sur le gène

human ... APP(351)

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

Description générale

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly present in the vascular amyloid deposits. Aβ40 comprises of C-terminal membrane insertion domain. It shows structural transition from random coil to a α-helical structure in a water-micelle medium.

Application

Amyloid β Protein Fragment 1-40 has been used:
  • in the temperature based conformational studies using Fourier transform infrared/differential scanning calorimetry (FT-IR/DSC) studies
  • as a reference standard in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of patients with head trauma
  • as a component of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Actions biochimiques/physiologiques

Amyloid β Protein Fragment 1-40 (Aβ40) forms cation based ion channels.
Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the major constituents of senile plaques and neurofibrillary tangles that occur in the hippocampus, neocortex, and amygdala of patients with Alzheimer′s disease.

Reconstitution

For maximal biological activity, dilute the stock in calcium-free PBS to 1 mg/ml and incubate at 37 °C for 4 days.

Autres remarques

Lyophilized from 0.1% TFA in H2O

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Solution Structure of Amyloid beta-Peptide (1- 40) in a Water- Micelle Environment. Is the Membrane-Spanning Domain Where We Think It Is?
Coles M, et al.
Biochemistry, 37(31), 11064-11077 (1998)
D R Howlett et al.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 4(1), 23-32 (1995-03-01)
The behaviour of synthetic batches of beta-amyloid (beta A) 1-40 peptide in solution has been studied. The effects of beta A1-40 on a PC12 cell toxicity assay was dependent upon the time of preincubation of an aqueous solution of the
H Funato et al.
The American journal of pathology, 152(4), 983-992 (1998-04-18)
Amyloid beta-protein (Abeta) is the major component of senile plaques that emerge in the cortex during aging and appear most abundantly in Alzheimer's disease. In the course of our immunocytochemical study on a large number of autopsy cases, we noticed
M Citron et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(23), 13170-13175 (1996-11-12)
Cerebral deposition of the amyloid beta protein (A beta) is an early and invariant feature of Alzheimer disease (AD). Whereas the 40-amino acid form of A beta (A beta 40) accounts for approximately 90% of all A beta normally released
Diversity of amyloid beta protein fragment [1-40]-formed channels
Kourie JI, et al.
Cellular and Molecular Neurobiology, 21(3), 255-284 (2001)
Afficher tous les articles scientifiques apparentés

Articles

Alzheimer's Disease

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique