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88908

Sigma-Aldrich

Methoxypolyethylene glycol 5,000 propionic acid

≥80%

Synonyme(s) :

Polyethylene glycol, O-(2-Carboxyethyl)-O′-methylpolyethylene glycol 5,000, mono-Methyl polyethylene glycol 5′000 propionic acid

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About This Item

Numéro MDL:
MFCD05665436
Code UNSPSC :
12352106
Nomenclature NACRES :
NA.25

Pureté

≥80%

Forme

lumps

Extrémité Ω

carboxylic acid

Extrémité α

methoxy

Température de stockage

−20°C

Application

Methoxypolyethylene glycol 5,000 propionic acid (M-SPA-PEG 5000) is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum half-life of proteins and enzymes.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Yihong Huang et al.
International journal of hematology, 92(4), 609-616 (2010-10-19)
We designed to determine whether pretreatment of allografts with methoxypolyethylene glycol-succinimidyl-propionic acid ester (mPEG-SPA) and an anti-OX40L monoclonal antibody (McAb) can relieve acute graft-versus-host disease in allogeneic bone marrow transplantation recipients. Responder splenocytes from C57BL/6 donor mice were incubated with
Y Tan et al.
Protein expression and purification, 12(1), 45-52 (1998-03-14)
Recombinant methioninase (rMETase) is a homotetrameric pyridoxal 5'-phosphate enzyme of 172-kda molecular mass derived from Pseudomonas putida and cloned in Escherichia coli. rMETase has been found previously to be an effective, anti-tumor agent in vitro and in vivo. The enzyme
Amanda J Bradley et al.
Biochimica et biophysica acta, 1561(2), 147-158 (2002-05-09)
Immunocamouflaged red blood cells (RBC) are produced by cell surface derivatization with methoxypolyethylene glycol (mPEG). These immunologically attenuated cells may reduce the risk of allosensitization in chronically transfused patients. To characterize the effects of differing linker chemistries and polymer lengths
Chun Zhang et al.
PloS one, 7(6), e39659-e39659 (2012-06-30)
Uricase has proven therapeutic value in treating hyperuricemia but sufficient reduction of its immunogenicity may be the largest obstacle to its chronic use. In this study, canine uricase was modified with 5 kDa mPEG-SPA and the impact of large aggregated

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