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202509

Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average Mn 2,000, methoxy, hydroxyl

Synonyme(s) :

Polyethylene glycol monomethyl ether

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About This Item

Formule linéaire :
CH3(OCH2CH2)nOH
Numéro CAS:
9004-74-4
Numéro MDL:
MFCD00084416
Code UNSPSC :
12162002
ID de substance PubChem :
24852095
Nomenclature NACRES :
NA.23

Nom du produit

Poly(ethylene glycol) methyl ether, average Mn ~2,000

Densité de vapeur

>1 (vs air)

Niveau de qualité

200

Pression de vapeur

0.05 mmHg ( 20 °C)

Forme

flakes (or pellets)

Poids mol.

average Mn ~2,000

Viscosité

54.6 cSt(210 °F)(lit.)

Température de transition

Tm 52 °C

Groupe fonctionnel

hydroxyl

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

Clé InChI

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Catégories apparentées

Description générale

It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.

Application

Poly(ethylene glycol) methyl ether-attached dendrimers can be used as carriers for anticancer drugs. This novel drug carrier has a biocompatible surface and an interior for the encapsulation of drugs.

It can be used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.

It can also be used as a starting material in the preparation of a biodegradable amphiphilic copolymer of poly(L-alanine) with mPEG.

Caractéristiques et avantages

Inserting poly(ethylene glycol) methyl ether (mPEG) side chain enhances the hydrophilicity and flexibility of the polymer matrix.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

359.6 °F - closed cup

Point d'éclair (°C)

182 °C - closed cup

Équipement de protection individuelle

Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
MKCQ7797
MKCN6678
MKCM6397
MKCM4215
MKCL9147

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Langmuir : the ACS journal of surfaces and colloids, 28(39), 13984-13992 (2012-09-04)
The microcosmic mechanisms of protein (recombinant human growth hormone, rhGH) incomplete release and stability from amphiphilic poly(monomethoxypolyethylene glycol-co-D,L-lactide) (mPEG-PLA, PELA) microspheres were investigated. PELA with different hydrophilicities (PELA-1, PELA-2, and PELA-3) based on various ratios of mPEG to PLA were
Prakash G Avaji et al.
Bioorganic & medicinal chemistry letters, 23(6), 1763-1767 (2013-02-16)
Saturated fatty acids (FA) were grafted using tyrosine as a spacer group to the cyclotriphosphazene ring along with equimolar hydrophilic methoxy poly(ethylene glycol) (MPEG) in cis-nongeminal way. Seven new cyclotriphosphazene amphiphiles were prepared from combinations of hydrophilic MPEGs with different
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
Junming Li et al.
Journal of biomedical nanotechnology, 8(5), 809-817 (2012-08-15)
In this study, quercetin (QC) with cancer chemoprevention effect and anticancer potential was loaded into polymeric micelles of methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol) in order to increase its water solubility. MPEG-Chol with lower critical micelle concentration (CMC) value (4.0 x
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