PHR1187

Acide rétinoïque

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonyme(s) : ATRA, Acide de vitamine A, Trétinoïne, acide tout-trans rétinoïque
• Formule empirique (notation de Hill): C₂₀H₂₈O₂
• Numéro CAS: 302-79-4
• Poids moléculaire : 300.44
• Beilstein: 2057223
• Numéro CE : 206-129-0
• Numéro MDL: MFCD00001551
• Code UNSPSC : 41116107
• ID de substance PubChem : 329823197
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material; pharmaceutical secondary standard
• Niveau de qualité: 300
• Agence: traceable to Ph. Eur. T1850000; traceable to USP 1674004
• Famille d'API: tretinoin
• Forme: solid
• CofA (certificat d'analyse): current certificate can be downloaded
• Technique(s): HPLC: suitable; gas chromatography (GC): suitable
• Pf: 180-181 °C (lit.)
• Application(s): food and beverages
• Format: neat
• Température de stockage: -10 to -25°C
• Chaîne SMILES: CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
• Clé InChI: SHGAZHPCJJPHSC-YCNIQYBTSA-N
• Informations sur le gène: human ... RARA(5914) , RARB(5915) , RARG(5916)

Description

Description générale

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tretinoin is a medication used for the treatment of severe cystic acne. The drug acts by regulating epithelial cell growth and differentiation, sebum production, collagen synthesis and keratinization of the skin.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Tretinoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Actions biochimiques/physiologiques

L′acide tout-−trans−rétinoïque (ATRA) est un ligand du récepteur de l′acide rétinoïque (RAR) et du récepteur X de rétinoïdes (RXR). Une fois liés, le RAR et le RXR agissent comme facteurs de transcription qui contrôlent la croissance et la différenciation des cellules normales et malignes. Les cytochromes P450 (CYP) catalysent la 4-hydroxylation de l′ATRA. L′acide rétinoïque conditionne la différenciation des cellules souches embryonnaires en neurones.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB7354 in the slot below. This is an example certificate only and may not be the lot that you receive.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H315,H360FD,H410
• Conseils de prudence: P202 - P264 - P273 - P301 + P312 - P302 + P352 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable