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95054

Supelco

Azelaic acid

analytical standard

Synonyme(s) :

Nonanedioic acid

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About This Item

Formule linéaire :
HO2C(CH2)7CO2H
Numéro CAS:
123-99-9
Poids moléculaire :
188.22
Beilstein:
1101094
Numéro CE :
204-669-1
Numéro MDL:
MFCD00004432
Code UNSPSC :
85151701
ID de substance PubChem :
329770414
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Densité de vapeur

6.5 (vs air)

Pression de vapeur

<1 mmHg ( 20 °C)

Essai

≥98.5% (GC)

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Impuretés

≤0.5% water

pb

286 °C/100 mmHg (lit.)

Pf

106-112 °C
109-111 °C (lit.)

Application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

Format

neat

Chaîne SMILES 

OC(=O)CCCCCCCC(O)=O

InChI

1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13)

Clé InChI

BDJRBEYXGGNYIS-UHFFFAOYSA-N

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Description générale

Azelaic acid (heptane-l,7-dicarboxylic acid), a dicarboxylic saturated acid, is an active component of some topical anti-acne preparations. It is reportedly identified in cosmetics and pharmaceuticals. Azelaic acid is found to suppress the growth of Propionibacterium spp. and reduce keratinization.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Application

Azelaic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
  • Tobacco using gas chromatography coupled to mass spectrometry (GC-MS).
  • Topical preparations using reversed-phase liquid chromatographic (LC) with UV-Vis detection.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

410.0 °F - closed cup

Point d'éclair (°C)

210 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number
BCCH0071
BCCF7961
BCCD1103
BCBZ4337
BCBS3271V

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Simultaneous determination of azelaic and benzoic acids in topical preparations by liquid chromatography
Mansour MA and Ibrahiem MM
Chromatographia, 55(7-8), 435-437 (2002)
James Q Del Rosso
Cutis, 77(2 Suppl), 22-24 (2006-03-29)
Topical azelaic acid (AzA) is approved for the treatment of acne vulgaris and inflammatory (papulopustular) rosacea. Because of diverse mechanisms of action that correlate with potential therapeutic benefit, AzA has been used to treat several common dermatoses including acne vulgaris
Boni Elewski et al.
Cutis, 77(2 Suppl), 12-16 (2006-03-29)
Azelaic acid (AzA) initially was released in a 20% cream formulation, which has been shown to be effective in the treatment of mild to moderate rosacea. Recently, a 15% gel formulation was developed that vastly improved the delivery of AzA
James E Frampton et al.
American journal of clinical dermatology, 5(1), 57-64 (2004-02-26)
Azelaic acid is a naturally occurring, straight-chain dicarboxylic acid which is effective in the treatment of rosacea, presumably on account of its anti-inflammatory properties. In randomized, double-blind, multicenter studies involving patients with moderate papulopustular facial rosacea, twice-daily topical application of
P S Mackrides et al.
American family physician, 54(8), 2457-2459 (1996-12-01)
Azelaic acid is another option for the topical treatment of mild to moderate inflammatory acne vulgaris. It offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl
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